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https://doi.org/10.3390/brainsci10050287
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DC Field | Value | Language |
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dc.contributor.author | Rasa-Dzelzkaleja, Santa | - |
dc.contributor.author | Gravelsina, Sabine | - |
dc.contributor.author | Chapenko, Svetlana | - |
dc.contributor.author | Nora-Krukle, Zaiga | - |
dc.contributor.author | Svirskis, Simons | - |
dc.contributor.author | Suna, Normunds | - |
dc.contributor.author | Kashuba, Elena | - |
dc.contributor.author | Karelis, Guntis | - |
dc.contributor.author | Murovska, Modra | - |
dc.date.accessioned | 2022-01-18T13:53:28Z | - |
dc.date.available | 2022-01-18T13:53:28Z | - |
dc.date.issued | 2020-05-11 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/7222 | - |
dc.description.abstract | Background: Human herpesviruses (HHV)-6A, HHV-6B and HHV-7 are considered to be involved in the pathogenesis of epilepsy, a common neurological disorder. The objective of this study was to determine the association of roseoloviruses infection with epilepsy. Methods: 53 epilepsy patients and 104 ordinary blood donors were analyzed to determine presence of virus-specific antibodies by enzyme-linked immunosorbent assay (ELISA) and immunofluorescence assay (IFA), genomic sequences, viral load and gene expression by polymerase chain reactions (PCRs) and restriction analysis, HHV-6 protein expression by IFA and level of cytokines by ELISA. Results: Roseoloviruses genomic sequences in DNA samples from whole blood were found in 86.8% of patients versus 54.8% of controls and active infection was revealed only in patients with epilepsy (19.6% of roseolovirus-positive patients). Significantly higher viral load and more frequent gene expression was detected in patients compared to the controls. HHV-6-encoded protein expression was demonstrated in 53.3% of patients with previously detected HHV-6 DNA. Changes in level of cytokines were determined in patients with elevated viral load compared to the patients without elevated viral loads and to the controls. Conclusions: Results on frequent active HHV-6 and HHV-7 infection in epilepsy patient’ peripheral blood indicate on possible involvement of these viruses in the disease development. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Brain Sciences, 10(5), [287]. | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | human herpesvirus-6 | en_US |
dc.subject | human herpesvirus-7 | en_US |
dc.subject | reactivation | en_US |
dc.subject | epilepsy | en_US |
dc.title | Persistent Roseoloviruses Infection in Adult Patients with Epilepsy | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.3390/brainsci10050287 | - |
Appears in Collections: | Publications |
Files in This Item:
File | Description | Size | Format | |
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Persistent Roseoloviruses Infection in Adult Patients with Epilepsy.pdf | 2.11 MB | Adobe PDF | View/Open |
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