Please use this identifier to cite or link to this item: https://doi.org/10.3390/brainsci10050287
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dc.contributor.authorRasa-Dzelzkaleja, Santa-
dc.contributor.authorGravelsina, Sabine-
dc.contributor.authorChapenko, Svetlana-
dc.contributor.authorNora-Krukle, Zaiga-
dc.contributor.authorSvirskis, Simons-
dc.contributor.authorSuna, Normunds-
dc.contributor.authorKashuba, Elena-
dc.contributor.authorKarelis, Guntis-
dc.contributor.authorMurovska, Modra-
dc.date.accessioned2022-01-18T13:53:28Z-
dc.date.available2022-01-18T13:53:28Z-
dc.date.issued2020-05-11-
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/7222-
dc.description.abstractBackground: Human herpesviruses (HHV)-6A, HHV-6B and HHV-7 are considered to be involved in the pathogenesis of epilepsy, a common neurological disorder. The objective of this study was to determine the association of roseoloviruses infection with epilepsy. Methods: 53 epilepsy patients and 104 ordinary blood donors were analyzed to determine presence of virus-specific antibodies by enzyme-linked immunosorbent assay (ELISA) and immunofluorescence assay (IFA), genomic sequences, viral load and gene expression by polymerase chain reactions (PCRs) and restriction analysis, HHV-6 protein expression by IFA and level of cytokines by ELISA. Results: Roseoloviruses genomic sequences in DNA samples from whole blood were found in 86.8% of patients versus 54.8% of controls and active infection was revealed only in patients with epilepsy (19.6% of roseolovirus-positive patients). Significantly higher viral load and more frequent gene expression was detected in patients compared to the controls. HHV-6-encoded protein expression was demonstrated in 53.3% of patients with previously detected HHV-6 DNA. Changes in level of cytokines were determined in patients with elevated viral load compared to the patients without elevated viral loads and to the controls. Conclusions: Results on frequent active HHV-6 and HHV-7 infection in epilepsy patient’ peripheral blood indicate on possible involvement of these viruses in the disease development.en_US
dc.language.isoenen_US
dc.relation.ispartofBrain Sciences, 10(5), [287].en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecthuman herpesvirus-6en_US
dc.subjecthuman herpesvirus-7en_US
dc.subjectreactivationen_US
dc.subjectepilepsyen_US
dc.titlePersistent Roseoloviruses Infection in Adult Patients with Epilepsyen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.3390/brainsci10050287-
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