Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Stanevicha, Valda | - |
dc.contributor.author | Eglite, Jelena | - |
dc.contributor.author | Sochnevs, Arturs | - |
dc.contributor.author | Gardovska, Dace | - |
dc.contributor.author | Zavadska, Dace | - |
dc.contributor.author | Shantere, Ruta | - |
dc.date.accessioned | 2021-10-01T13:55:01Z | - |
dc.date.available | 2021-10-01T13:55:01Z | - |
dc.date.issued | 2003 | - |
dc.identifier.citation | Stanevicha , V , Eglite , J , Sochnevs , A , Gardovska , D , Zavadska , D & Shantere , R 2003 , ' HLA class II associations with rheumatic heart disease among clinically homogeneous patients in children in Latvia. ' , Arthritis research & therapy , vol. 5 , no. 6 , pp. R340-346 . < https://www-sciencedirect-com.db.rsu.lv/science/article/pii/S1297319X07000450?via%3Dihub > | - |
dc.identifier.issn | 1478-6354 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/6489 | - |
dc.description | Copyright: This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine | - |
dc.description.abstract | Genetic control of immune reactions has a major role in the development of rheumatic heart disease (RHD) and differs between patients with rheumatic fever (RF). Some authors think the risk of acquiring RHD is associated with the HLA class II DR and DQ loci, but other views exist, due to the various HLA-typing methods and ways of grouping cases. Our goal was to determine the relations between HLA class II alleles and risk of or protection from RF in patients with relatively homogeneous clinical manifestations. A total of 70 RF patients under the age of 18 years were surveyed in Latvia. HLA genotyping of DRB1*01 to DRB1*18 and DQB1*0201-202, *0301-305, *0401-402, *0501-504, and *0601-608 was performed using polymerase chain reaction sequence-specific primers. Data for a control group of 100 healthy individuals typed for HLA by the same method were available from the databank of the Immunology Institute of Latvia. Of the RF patients, 47 had RHD and 8 had Sydenham's chorea. We concluded that HLA class II DRB1*07-DQB1*0401-2 and DRB1*07-DQB1*0302 could be the risk alleles and HLA class II DRB1*06 and DQB1*0602-8, the protective ones. Patients with mitral valve regurgitation more often had DRB1*07 and DQB1*0401-2, and patients with multivalvular lesions more often had DRB1*07 and DQB1*0302. In Sydenham's chorea patients, the DQB1*0401-2 allele was more frequent. Genotyping control showed a high risk of RF and RHD in patients with DRB1*01-DQB1*0301-DRB1*07-DQB1*0302 and DRB1*15-DQB1*0302-DRB1*07-DQB1*0303. | en |
dc.format.extent | 152940 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Arthritis research & therapy | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | 3.1 Basic medicine | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | Rheumatology | - |
dc.subject | Immunology and Allergy | - |
dc.subject | Immunology | - |
dc.title | HLA class II associations with rheumatic heart disease among clinically homogeneous patients in children in Latvia. | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.contributor.institution | Department of Paediatrics | - |
dc.contributor.institution | Joint Laboratory of Clinical Immunology and Immunogenetics | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=2442538292&partnerID=8YFLogxK | - |
dc.identifier.url | https://www-sciencedirect-com.db.rsu.lv/science/article/pii/S1297319X07000450?via%3Dihub | - |
dc.identifier.url | https://arthritis-research.biomedcentral.com/articles/10.1186/ar1000 | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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