Please use this identifier to cite or link to this item:
10.32471/exp-oncology.2312-8852.vol-42-no-4.15289
Title: | Dickkopf-related protein 1 expression in bone marrow of multiple myeloma patients : correlation with bone disease and plasma cell malignancy type |
Authors: | Auziņa, D Beinaroviča, I Janicka-Kupra, B Lejniece, S Lejnieks, A Groma, V Rīga Stradiņš University Institute of Anatomy and Anthropology |
Keywords: | 3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database |
Issue Date: | Dec-2020 |
Citation: | Auziņa , D , Beinaroviča , I , Janicka-Kupra , B , Lejniece , S , Lejnieks , A & Groma , V 2020 , ' Dickkopf-related protein 1 expression in bone marrow of multiple myeloma patients : correlation with bone disease and plasma cell malignancy type ' , Experimental Oncology , vol. 42 , no. 4 , pp. 285-288 . https://doi.org/10.32471/exp-oncology.2312-8852.vol-42-no-4.15289 |
Abstract: | BACKGROUND: Previous studies have pointed out the role of dickkopf-related protein 1 (DKK 1) - Wnt inhibitor, which is essential for osteoblast functioning, in the development of osteolytic lesions in multiple myeloma (MM). AIM: To assess the DKK 1 expression displayed by myeloma cells in bone marrow trephine biopsies of patients with and without osteolytic lesions, and in different malignancy grades of the disease. METHODS: The expression level of DKK 1 was assessed immunohistochemically in bone marrow of 49 MM patients presented with and without osteolytic lesions (the 1st and the 2nd group, respectively). RESULTS: Levels of weak, moderate, and strong DKK 1 expression were distributed - as 43.33, 27.78 and 25.56%, and 63.91, 18.80, and 1.50%, respectively when evaluating the samples obtained from the 1st and the 2nd group. Statistically significant differences were found when the levels of DKK 1 expression in the 1st and the 2nd group were compared (χ2 = 51; df = 3; p < 0.001). CONCLUSIONS: DKK 1 contributes to the development of osteolytic lesions in MM. The present study provides morphological evidence that inhibition in Wnt signaling may lead to bone damage observed in the advanced stage of the disease. |
Description: | Autoru afiliācijas atšķiras PDF versijā, žurnāla versijā, Pubmed un Web of Science datubāzēs. |
DOI: | 10.32471/exp-oncology.2312-8852.vol-42-no-4.15289 |
ISSN: | 1812-9269 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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Dickkopf_related_protein_1_expression.pdf | 653.69 kB | Adobe PDF | View/Open |
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