Please use this identifier to cite or link to this item:
10.2478/v10046-011-0012-6
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DC Field | Value | Language |
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dc.contributor.author | Mačuks, Ronalds | - |
dc.contributor.author | Baidekalna, Ieva | - |
dc.contributor.author | Nuķe, Inta | - |
dc.contributor.author | Doniņa, Simona | - |
dc.date.accessioned | 2021-08-18T08:45:01Z | - |
dc.date.available | 2021-08-18T08:45:01Z | - |
dc.date.issued | 2011-01-01 | - |
dc.identifier.citation | Mačuks , R , Baidekalna , I , Nuķe , I & Doniņa , S 2011 , ' Seruma šķīstošā interleikīna 2 receptora alfa (sIL-R2α) un CA-125 kombinētais tests olnīcu vēža diagnostikai ' , Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences , vol. 65 , no. 1-2 , pp. 7-12 . https://doi.org/10.2478/v10046-011-0012-6 | - |
dc.identifier.issn | 1407-009X | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/6034 | - |
dc.description.abstract | Detection of ovarian cancer can be improved using a combined diagnostic test consisting of Ca-125 and serum interleukine-2 receptor alpha (sIL-R2α) at a particular threshold. The objective of the study was to evaluate the accuracy of a diagnostic marker assay that combined Ca-125 and serum interleukine-2 receptor alpha. A case-control study of 38 patients with ovarian cancer, 40 patients with benign ovarian diseases and 31 age-matched healthy controls was designed. Ca-125 and sIL-2Rα were detected in patients' serum by standardized chemiluminescent immunometric assays. For Ca-125, a standard cutoff level of 21 U/ml was applied and for sIL-R2α - two cutoff levels were calculated from women included in the control group - one as a mean concentration and the other as an upper limit of a 95% confidence interval. Mean serum concentrations among ovarian cancer patients for CA125 and sIL-2Rα were 265.9 ± 40.2 U/ml and 651.0 ± 50.5 U/ml, respectively. The upper limit of the 95% confidence interval for a healthy control group of women was 304.5 U/ml for sIL-2Rα. Sensitivity and specificity of 89.4% and 85.9% was achieved when CA125 was combined together with sIL-2Rα at a threshold of 304.5U/ml with the condition that both markers are elevated. Sensitivity and specificity of 92.5% and 88.4% was observed when both biomarkers were applied to menopausal women. Serum sIL-2Rα in combination with CA125 can be used as a differential diagnostic test for ovarian cancer at a specific threshold, especially among menopausal women. | en |
dc.format.extent | 6 | - |
dc.format.extent | 118628 | - |
dc.language.iso | lav | - |
dc.relation.ispartof | Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Ca125 | - |
dc.subject | diagnostics | - |
dc.subject | interleukine-2 receptor alpha | - |
dc.subject | ovarian cancer | - |
dc.subject | screening | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | General | - |
dc.subject | SDG 3 - Good Health and Well-being | - |
dc.title | Seruma šķīstošā interleikīna 2 receptora alfa (sIL-R2α) un CA-125 kombinētais tests olnīcu vēža diagnostikai | lv |
dc.title.alternative | Role of a combined soluble interleukine-2 receptor alpha (sIL-R2α) and CA-125 serum marker assay for detection of ovarian cancer | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.2478/v10046-011-0012-6 | - |
dc.contributor.institution | Rīga Stradiņš University | - |
dc.contributor.institution | Institute of Microbiology and Virology | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=80054757238&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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Role_of_a_combined_soluble_interleukine.pdf | 115.85 kB | Adobe PDF | View/Open |
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