Please use this identifier to cite or link to this item: 10.2478/prolas-2021-0012
Title: Expression and localisation of cd44 antigen as a prognostic factor of oral leukoplakia
Authors: Dzudzilo, Madara
Kleina, Regīna
Čēma, Ingrīda
Dabuzinskiene, Anita
Svirskis, Šimons
Department of Doctoral Studies
Department of Pathology
Rīga Stradiņš University
Institute of Microbiology and Virology
Keywords: cell-surface glycoprotein;oral precancers;mononuclear cells of lamina propria;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;SDG 3 - Good Health and Well-being
Issue Date: 1-Apr-2021
Citation: Dzudzilo , M , Kleina , R , Čēma , I , Dabuzinskiene , A & Svirskis , Š 2021 , ' Expression and localisation of cd44 antigen as a prognostic factor of oral leukoplakia ' , Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences. , vol. 75 , no. 2 , pp. 68-74 . https://doi.org/10.2478/prolas-2021-0012
Abstract: It is essential to identify markers that could indicate the presence of early molecular changes in premalignant tissues like oral leukoplakia (OL). CD44 adhesion molecule is not only a stem cell marker, but also determines cell proliferation and migration in malignant processes. The aim of our study was to assess the amount and pattern of CD44 antigen expression by epithelial and mononuclear cells in the lamina propria under OL and their role in premalignant lesions. The current study included 102 cases of OL and ten biopsies from healthy oral mucosa. Immunohistochemical CD44 antigen expression was determined in 34 cases by a standard EnVision imaging system in three points of OL: both edges and centre. Statistical analysis was done using GraphPad Prism software version 8.4.0. In OL, statistically significant overexpression of membranous CD44 was demonstrated compared to healthy mucosa (p < 0.0001). The intra-cytoplasmatic CD44 expression of epithelium together with characteristic nuclear changes may be used as a predictive factor for potential malignant transformation of non-homogenous leukoplakia. CD44 expression in mononuclear cells under the basal membrane in OL (p < 0.05) possibly influences the process of premalignant lesion transformation into intraepithelial cancer. Further study of CD44 antigen expression in intra-cytoplasmatic structures is required for better explanation of the role of this glycoprotein.
Description: Publisher Copyright: © 2021 Sciendo. All rights reserved.
DOI: 10.2478/prolas-2021-0012
ISSN: 2255-890X
Appears in Collections:Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure

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