Please use this identifier to cite or link to this item: 10.1530/EJE-15-0879
Title: Polymorphisms in MEN1 and DRD2 genes are associated with the occurrence and characteristics of pituitary adenomas
Authors: Peculis, Raitis
Balcere, Inga
Rovite, Vita
Megnis, Kaspars
Valtere, Andra
Stukens, Janis
Arnicane, Ligita
Nikitina-Zake, Liene
Lejnieks, Aivars
Pirags, Valdis
Klovins, Janis
Keywords: 3.1 Basic medicine;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;Endocrinology, Diabetes and Metabolism;Endocrinology;SDG 3 - Good Health and Well-being
Issue Date: Aug-2016
Citation: Peculis , R , Balcere , I , Rovite , V , Megnis , K , Valtere , A , Stukens , J , Arnicane , L , Nikitina-Zake , L , Lejnieks , A , Pirags , V & Klovins , J 2016 , ' Polymorphisms in MEN1 and DRD2 genes are associated with the occurrence and characteristics of pituitary adenomas ' , European Journal of Endocrinology , vol. 175 , no. 2 , pp. 145-153 . https://doi.org/10.1530/EJE-15-0879
Abstract: Objective: Although pituitary adenomas (PAs) affect a significant proportion of the population, only a fraction have the potential to become clinically relevant during an individual's lifetime, causing hormonal imbalance or complications due to mass effect. The overwhelming majority of cases are sporadic and without a clear familial history, and the genotype-phenotype correlation in PA patients is poorly understood. Our aim was to investigate the involvement of genes known for their role in familial cases on drug response and tumor suppression in the development and pathology of PAs in a patient group from Latvia. Design: The study included 143 cases and 354 controls, we investigated the role of single-nucleotide polymorphisms (SNPs) in seven genes (SSTR2, SSTR5, DRD2, MEN1, AIP, GNAS, and PRKAR1A) associated with pituitary tumor occurrence, phenotype, and clinical symptoms. Methods: Genotyping of 96 tag and nonsynonymous SNPs was performed in the genomic regions of interest. Results: We discovered a significant association (OR = 17.8, CI 0.95 = 2.18-145.5, P = 0.0002) between a rare MEN1 mutation (rs2959656) and clinically active adenoma in our patients. Additionally, rs7131056 at DRD2 was associated with a higher occurrence of extrasellar growth in patients with prolactinoma and somatotropinoma (OR = 2.79, CI 0.95 = 1.58-4.95, P = 0.0004). Conclusions: rs2959656, a nonsynonymous variant in MEN1, is associated with the development of clinically active PA. Furthermore, rs7131056 in DRD2 contributes to either faster growth of the adenoma or reduced symptomatic presentation, allowing PAs to become larger before detection.
Description: Publisher Copyright: © 2016 European Society of Endocrinology Published by Bioscientifica Ltd. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.
DOI: 10.1530/EJE-15-0879
ISSN: 0804-4643
Appears in Collections:Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure

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