Please use this identifier to cite or link to this item: 10.1186/s12920-020-00860-4
Title: Novel susceptibility loci identified in a genome-wide association study of type 2 diabetes complications in population of Latvia
Authors: Ustinova, Monta
Peculis, Raitis
Rescenko, Raimonds
Rovite, Vita
Zaharenko, Linda
Elbere, Ilze
Silamikele, Laila
Konrade, Ilze
Sokolovska, Jelizaveta
Pirags, Valdis
Klovins, Janis
Faculty of Medicine
Keywords: Diabetic complications;Genome-wide genotyping;Type 2 diabetes mellitus;3.2 Clinical medicine;1.6 Biological sciences;1.1. Scientific article indexed in Web of Science and/or Scopus database;Genetics;Genetics(clinical);SDG 3 - Good Health and Well-being
Issue Date: 2021
Citation: Ustinova , M , Peculis , R , Rescenko , R , Rovite , V , Zaharenko , L , Elbere , I , Silamikele , L , Konrade , I , Sokolovska , J , Pirags , V & Klovins , J 2021 , ' Novel susceptibility loci identified in a genome-wide association study of type 2 diabetes complications in population of Latvia ' , BMC Medical Genomics , vol. 14 , no. 1 , 18 . https://doi.org/10.1186/s12920-020-00860-4
Abstract: Background: Type 2 diabetes complications cause a serious emotional and economical burden to patients and healthcare systems globally. Management of both acute and chronic complications of diabetes, which dramatically impair the quality of patients' life, is still an unsolved issue in diabetes care, suggesting a need for early identification of individuals with high risk for developing diabetes complications. Methods: We performed a genome-wide association study in 601 type 2 diabetes patients after stratifying them according to the presence or absence of four types of diabetes complications: diabetic neuropathy, diabetic nephropathy, macrovascular complications, and ophthalmic complications. Results: The analysis revealed ten novel associations showing genome-wide significance, including rs1132787 (GYPA, OR = 2.71; 95% CI = 2.02–3.64) and diabetic neuropathy, rs2477088 (PDE4DIP, OR = 2.50; 95% CI = 1.87–3.34), rs4852954 (NAT8, OR = 2.27; 95% CI = 2.71–3.01), rs6032 (F5, OR = 2.12; 95% CI = 1.63–2.77), rs6935464 (RPS6KA2, OR = 2.25; 95% CI = 6.69–3.01) and macrovascular complications, rs3095447 (CCDC146, OR = 2.18; 95% CI = 1.66–2.87) and ophthalmic complications. By applying the targeted approach of previously reported susceptibility loci we managed to replicate three associations: MAPK14 (rs3761980, rs80028505) and diabetic neuropathy, APOL1 (rs136161) and diabetic nephropathy. Conclusions: Together these results provide further evidence for the implication of genetic factors in the development of type 2 diabetes complications and highlight several potential key loci, able to modify the risk of developing these conditions. Moreover, the candidate variant approach proves a strong and consistent effect for multiple variants across different populations.
Description: Funding Information: The study was supported by European Regional Development Fund (ERDF) On Implementation of Activity 1.1.1.2 “Post-doctoral Research Aid” of the Specific Aid Objective 1.1.1 “To increase the research and innovative capacity of scientific institutions of Latvia and the ability to attract external financing, investing in human resources and infrastructure” of the Operational Programme “Growth and Employment”. Project No 1.1.1.2/VIAA/2/18/287 “Identification of clinical subgroups of Type 2 diabetes mellitus and application of pharmacogenetics in the development of personalized antidiabetic therapy”. The funding body was not involved in the design of the study, collection, analysis or interpretation of data, or writing the manuscript. Publisher Copyright: © 2021, The Author(s).
DOI: 10.1186/s12920-020-00860-4
ISSN: 1755-8794
Appears in Collections:Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure

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