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  2. Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure
  3. Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure
Please use this identifier to cite or link to this item: 10.1016/j.dib.2019.104623
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dc.contributor.authorSvalbe, Baiba-
dc.contributor.authorGrinberga, Solveiga-
dc.contributor.authorStelfa, Gundega-
dc.contributor.authorVavers, Edijs-
dc.contributor.authorZvejniece, Baiba-
dc.contributor.authorSevostjanovs, Eduards-
dc.contributor.authorDambrova, Maija-
dc.contributor.authorZvejniece, Liga-
dc.date.accessioned2021-04-28T07:50:02Z-
dc.date.available2021-04-28T07:50:02Z-
dc.date.issued2019-12-
dc.identifier.citationSvalbe , B , Grinberga , S , Stelfa , G , Vavers , E , Zvejniece , B , Sevostjanovs , E , Dambrova , M & Zvejniece , L 2019 , ' Data on analysis of MK-801 bioavailability in mouse plasma and brain tissue by ultra-performance liquid chromatography-tandem mass spectrometry ' , Data in Brief , vol. 27 , 104623 . https://doi.org/10.1016/j.dib.2019.104623-
dc.identifier.issn2352-3409-
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/3949-
dc.descriptionFunding Information: This research was supported by the European Regional Development Fund (ERDF) project No. 1.1.1.2/VIAA/1/16/244 “The role of sigma-1 receptor in sexual behavior”. Publisher Copyright: © 2019 The Author(s)-
dc.description.abstractMK-801, a N-methyl-D-aspartate receptor antagonist, is widely used in animal preclinical experiments to induce memory and learning impairments and schizophrenia-like behavior. In the present study, we compared the plasma and brain tissue concentrations of MK-801 after intraperitoneal (i.p.) or subcutaneous (s.c.) administration at a dose of 0.1 mg/kg in male ICR mice. Moreover, these data present the optimization of ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for the analysis of MK-801 in biological samples. Procedures for the preparation of brain tissue and plasma samples and instrumental analysis are described. This article is related to a research article entitled “Effects of the N-methyl-D-aspartate receptor antagonist, MK-801, on spatial memory and influence of the route of administration” [1].en
dc.format.extent456019-
dc.language.isoeng-
dc.relation.ispartofData in Brief-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.subjectBioavailability-
dc.subjecti.p. and s.c. administration route-
dc.subjectMice-
dc.subjectMK-801-
dc.subjectUPLC-MS/MS-
dc.subject3.1 Basic medicine-
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database-
dc.subjectGeneral-
dc.titleData on analysis of MK-801 bioavailability in mouse plasma and brain tissue by ultra-performance liquid chromatography-tandem mass spectrometryen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article-
dc.identifier.doi10.1016/j.dib.2019.104623-
dc.contributor.institutionRīga Stradiņš University-
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85068505948&partnerID=8YFLogxK-
dc.description.statusPeer reviewed-
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