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Title: Presence of human bocavirus 1 and other respiratory viruses in children with lower respiratory tract infection in Latvia
Authors: Vilmane, Anda
Ziemele, Inga
Rasa, Santa
Terentjeva, Anna
Murovska, Modra
Gardovska, Dace
Lin, Yung Cheng
Nora-Krukle, Zaiga
Institute of Microbiology and Virology
Department of Paediatrics
Faculty of Medicine
Keywords: infants;multiplex polymerase chain reaction;parvovirus;1.6 Biological sciences;3.1 Basic medicine;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;General;SDG 3 - Good Health and Well-being
Issue Date: 1-May-2019
Citation: Vilmane , A , Ziemele , I , Rasa , S , Terentjeva , A , Murovska , M , Gardovska , D , Lin , Y C & Nora-Krukle , Z 2019 , ' Presence of human bocavirus 1 and other respiratory viruses in children with lower respiratory tract infection in Latvia ' , Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences , vol. 73 , no. 2 , pp. 132-138 .
Abstract: Lower respiratory tract infection (LRTI) is the major cause of morbidity and mortality of children in the world. In addition to respiratory syncytial virus, influenza virus types A and B, parainfluenza types 1, 2 and 3, and adenoviruses, several new respiratory viruses associated with LRTI were discovered in the 21 st century. These are metapneumovirus, coronaviruses NL63 and HKU1, parainfluenza virus type four and human bocavirus one (HBoV1). HBoV1 was discovered in 2005 and is considered as the fourth most prevalent respiratory virus worldwide. However, the high frequency of co-infections detected together with HBoV1 raises doubt about whether HBoV1 is a true pathogen or just a bystander. This is the first study aimed to determine the presence of HBoV1 and 18 other respiratory viruses in nasopharyngeal aspirates (NPA) of children with LRTI in Latvia. Using multiplex real-time polymerase chain reaction method, the HBoV1 genomic sequence was detected in 60.0% of NPA samples, showing that HBoV1 prevalence is high among children with LRTI in Latvia. HBoV1 mono-infection was revealed in 6.67%. The most common co-infections associated with HBoV1 were rhinovirus, adenovirus, respiratory syncytial virus A and B, metapneumovirus, and enterovirus.
Description: Publisher Copyright: © 2019 Anda Vilmane et al., published by Sciendo 2019. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.
ISSN: 1407-009X
Appears in Collections:Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure

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