Please use this identifier to cite or link to this item:
10.1371/journal.pone.0305120
Title: | Tick-borne encephalitis infections without CNS involvement : An observational study in Latvia, 2007-2022 |
Authors: | Freimane, Zane Karelis, Guntis Zolovs, Maksims Zavadska, Dace Rīga Stradiņš University Department of Infectology Statistics Unit |
Keywords: | Humans;Encephalitis, Tick-Borne/epidemiology;Latvia/epidemiology;Male;Female;Middle Aged;Adult;Encephalitis Viruses, Tick-Borne;Aged;Adolescent;Young Adult;Child;Child, Preschool;Central Nervous System/virology;Aged, 80 and over;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;SDG 3 - Good Health and Well-being |
Issue Date: | Jun-2024 |
Citation: | Freimane , Z , Karelis , G , Zolovs , M & Zavadska , D 2024 , ' Tick-borne encephalitis infections without CNS involvement : An observational study in Latvia, 2007-2022 ' , PloS one , vol. 19 , no. 6 June , e0305120 . https://doi.org/10.1371/journal.pone.0305120 |
Abstract: | BACKGROUND: Tick-borne encephalitis (TBE) is a human viral infectious disease involving the central nervous system (CNS). It is caused by the tick-borne encephalitis virus (TBEV). At present, there is very limited information regarding the clinical importance and health burden of TBE infections without signs of CNS inflammation. Moreover, such cases are omitted from official TBE surveillances and there are no reports of population-based studies. METHODS AND FINDINGS: A nationwide population-based study was conducted in Latvia by intensively searching for symptomatic TBEV infections recorded in outpatient and hospital settings between 2007 and 2022. In total, 4,124 symptomatic TBEV infections were identified, of which 823 (20.0%) had no CNS involvement. Despite the lack of neurological symptoms, non-CNS TBE patients still experienced severe health conditions that required management in a hospital setting for a median duration of 7 days. Furthermore, lumbar puncture information was available for 708 of these patients, with 100 (14.1%) undergoing the procedure, suggesting a high suspicion of CNS involvement. CONCLUSIONS: Clearly, non-CNS TBE has the potential to negatively impact the health of patients. The actual burden of non-CNS TBEV cases may be higher than we think as these cases are omitted from official TBE surveillances and are challenging to recognize. |
Description: | Publisher Copyright: © 2024 Public Library of Science. All rights reserved. |
DOI: | 10.1371/journal.pone.0305120 |
ISSN: | 1932-6203 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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Tick-borne_encephalitis_infections_without.pdf | 578.95 kB | Adobe PDF | View/Open |
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