Please use this identifier to cite or link to this item:
10.3390/pharmaceutics16050586
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DC Field | Value | Language |
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dc.contributor.author | Kovalenko, Lakija | - |
dc.contributor.author | Kukuls, Kirils | - |
dc.contributor.author | Berga, Marta | - |
dc.contributor.author | Mohylyuk, Valentyn | - |
dc.date.accessioned | 2024-05-03T09:10:04Z | - |
dc.date.available | 2024-05-03T09:10:04Z | - |
dc.date.issued | 2024-05 | - |
dc.identifier.citation | Kovalenko , L , Kukuls , K , Berga , M & Mohylyuk , V 2024 , ' Taste-Masked Pellets of Warfarin Sodium : Formulation towards the Dose Personalisation ' , Pharmaceutics , vol. 16 , no. 5 , 586 . https://doi.org/10.3390/pharmaceutics16050586 | - |
dc.identifier.issn | 1999-4923 | - |
dc.identifier.other | Mendeley: dce5455a-7242-3ec8-b38c-94fecc53e4dc | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/15463 | - |
dc.description | Publisher Copyright: © 2024 by the authors. | - |
dc.description.abstract | The bitter drug, warfarin, has a narrow therapeutic index (NTI) and is used in paediatrics and geriatrics. The aim of this feasibility study was to formulate the taste-masked warfarin-containing pellets to be applicable for dose personalisation and to improve patient compliance, as well as to investigate the effect of the core type (PharSQ® Spheres M, CELPHERE™ CP-507, and NaCl) on the warfarin release from the Kollicoat® Smartseal taste-masking-coated pellets. The cores were successfully drug-loaded and coated in a fluid-bed coater with a Wurster insert. An increase in particle size and particle size distribution was observed by optical microscopy. In saliva-simulated pH, at the Kollicoat® Smartseal level of 2 mg/cm2, none of the pellets demonstrated drug release, confirming their efficient taste-masking. However, in a stomach-simulated pH, a faster drug release was observed from PharSQ® Spheres M- and CELPHERE™ CP-507-coated pellets in comparison with NaCl cores. Additional experiments allowed us to explain the slower drug release from NaCl-containing pellets because of the salting-out effect. Despite the successful taste masking, the drug release from pellets was relatively slow (not more than 91% per 60 min), allowing for further formulation improvements. | en |
dc.format.extent | 13853140 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Pharmaceutics | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | warfarin | - |
dc.subject | pellets | - |
dc.subject | taste | - |
dc.subject | taste masking | - |
dc.subject | cores | - |
dc.subject | microcrystalline cellulose | - |
dc.subject | dibasic calcium phosphate | - |
dc.subject | sodium chloride | - |
dc.subject | Kollicoat® Smartseal | - |
dc.subject | dibutyl sebacate | - |
dc.subject | salting-out effect | - |
dc.subject | 1.4 Chemical sciences | - |
dc.subject | 2.4 Chemical engineering | - |
dc.subject | 2.5 Materials engineering | - |
dc.subject | 3.1 Basic medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.title | Taste-Masked Pellets of Warfarin Sodium : Formulation towards the Dose Personalisation | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.3390/pharmaceutics16050586 | - |
dc.contributor.institution | Laboratory of Finished Dosage Forms | - |
dc.identifier.url | https://www.mendeley.com/catalogue/dce5455a-7242-3ec8-b38c-94fecc53e4dc/ | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85194384486&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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File | Size | Format | |
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pharmaceutics-16-00586.pdf | 13.53 MB | Adobe PDF | View/Open |
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