Please use this identifier to cite or link to this item:
10.15388/Amed.2023.30.1.5
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Panina, Aleksandra | - |
dc.contributor.author | Ligere, Elīna | - |
dc.contributor.author | Aleksejeva, Elīna | - |
dc.contributor.author | Davidsone, Zane | - |
dc.contributor.author | Cebure, Elizabete | - |
dc.contributor.author | Erdmane, Irina | - |
dc.date.accessioned | 2023-11-30T16:40:01Z | - |
dc.date.available | 2023-11-30T16:40:01Z | - |
dc.date.issued | 2023-01-24 | - |
dc.identifier.citation | Panina , A , Ligere , E , Aleksejeva , E , Davidsone , Z , Cebure , E & Erdmane , I 2023 , ' Eosinophilic Granulomatosis with Polyangiitis in an 8-year-old Girl Manifesting as Hypereosinophilic Syndrome with Myocarditis, Stroke, and Subsequent Orbital Involvement ' , Acta medica Lituanica , vol. 30 , no. 1 , pp. 45-52 . https://doi.org/10.15388/Amed.2023.30.1.5 | - |
dc.identifier.issn | 1392-0138 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/15018 | - |
dc.description | Copyright © 2023 A. Panina Aleksandra, Ligere Elīna, Aleksejeva Elīna, Davidsone Zane, Cebure Elizabete, Erdmane Irina. Published by Vilnius University Press. | - |
dc.description.abstract | Hypereosinophilic syndrome (HES) is a heterogeneous group of disorders characterized by peripheral blood eosinophilia of 1.5 × 109/L (1,500/μL) or greater, with evidence of end-organ damage attributable to eosinophilia (e.g., heart, liver or lung) with no other cause for the end-organ damage [1]. Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare disorder that may affect multiple organ systems (lungs, heart, kidneys, or the nervous system). The disorder is characterized by hypereosinophilia in the blood and tis-sues, inflammation of blood vessels (vasculitis), and the development of inflammatory nodular lesions called granulomatosis [2]. We report a case with a 9-year-old girl presenting with severe hypereosinophilia, ischemic stroke, right-sided hemiparesis and myocarditis treated with methylprednisolone, enoxaparin, rivaroxaban and carvedilol. The patient recovered successfully from myocarditis and stroke but manifested with right-sided orbital involvement as pre-and post-septal orbital cellulitis 10 months later with necrotizing granu-lomatous perivascular chronic infiltration with eosinophilic infiltration treated with methylprednisolone and subsequent mepolizumab with successful remission of orbital involvement, but severe exogenous Cushing’s syndrome and myocardial fibrosis. | en |
dc.format.extent | 8 | - |
dc.format.extent | 2517341 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | Acta medica Lituanica | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Churg–Strauss syn-drome | - |
dc.subject | eosinophilic myocarditis | - |
dc.subject | orbital involvement | - |
dc.subject | paediatric hypereosinophilic syndrome | - |
dc.subject | stroke | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | General Medicine | - |
dc.title | Eosinophilic Granulomatosis with Polyangiitis in an 8-year-old Girl Manifesting as Hypereosinophilic Syndrome with Myocarditis, Stroke, and Subsequent Orbital Involvement | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.15388/Amed.2023.30.1.5 | - |
dc.contributor.institution | Department of Paediatrics | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85164140016&partnerID=8YFLogxK | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
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Eosinophilic_Granulomatosis_with.pdf | 2.46 MB | Adobe PDF | View/Open |
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