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10.1136/bmjopen-2022-069558
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DC Field | Value | Language |
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dc.contributor.author | Pärna, Kersti | - |
dc.contributor.author | Nygård, Mari | - |
dc.contributor.author | Tisler, Anna | - |
dc.contributor.author | Toompere, Karolin | - |
dc.contributor.author | Naaber, Paul | - |
dc.contributor.author | Ratnik, Kaspar | - |
dc.contributor.author | Ķīvīte Urtāne, Anda | - |
dc.contributor.author | Zodzika, Jana | - |
dc.contributor.author | Stankūnas, Mindaugas | - |
dc.contributor.author | Baltzer, Nicholas | - |
dc.contributor.author | Uusküla, Anneli | - |
dc.date.accessioned | 2023-06-12T08:30:01Z | - |
dc.date.available | 2023-06-12T08:30:01Z | - |
dc.date.issued | 2023-06-01 | - |
dc.identifier.citation | Pärna , K , Nygård , M , Tisler , A , Toompere , K , Naaber , P , Ratnik , K , Ķīvīte Urtāne , A , Zodzika , J , Stankūnas , M , Baltzer , N & Uusküla , A 2023 , ' Age-specific and genotype-specific carcinogenic human papillomavirus prevalence in a country with a high cervical cancer burden : results of a cross-sectional study in Estonia ' , BMJ Open , vol. 13 , no. 6 , e069558 , pp. e069558 . https://doi.org/10.1136/bmjopen-2022-069558 | - |
dc.identifier.issn | 2044-6055 | - |
dc.identifier.other | Mendeley: 02370585-ebc2-3af6-9a0b-8b267d5b113e | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/12328 | - |
dc.description | © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. | - |
dc.description.abstract | OBJECTIVES: To describe age-specific and type-specific carcinogenic human papillomavirus (HPV) prevalence prior to large-scale effect of HPV vaccines in Estonia and to analyse the risk factors associated with carcinogenic HPV. DESIGN: Cross-sectional study using self-administered questionnaire and self-collected vaginal swabs for detection of HPV infection. SETTING: Estonian Biobank database. PARTICIPANTS: Stratified random sample of women aged 30-33, 57-60 and 67-70 years living in one of the three largest counties in Estonia. Of 3065 women approached, 1347 (43.9%) returned questionnaires and specimens for HPV DNA detection. OUTCOME MEASURES: HPV prevalence and fully adjusted ORs with 95% CIs for risk factors. RESULTS: HPV prevalence was highest among women aged 30-33 years (18.7%; 95% CI 15.8 to 21.9) followed by those aged 67-70 years (16.7%; 95% CI 12.4 to 22.0) and 57-60 years (10.2%; 95% CI 7.8 to 13.3). HPV16 and HPV56 were the most common among women aged 30-33 years (both 4.0%; 95% CI 2.7 to 5.9), and HPV68 was the most common among women aged 57-60 years (2.8%; 95% CI 1.5 to 4.7) and 67-70 years (6.4%; 95% CI 3.6 to 10.4). Vaccination with nonavalent vaccine would have halved the carcinogenic HPV prevalence among women aged 30-33 years. The odds of infection with carcinogenic HPV were higher among women with six or more sexual partners among younger (OR 2.99; 95% CI 1.54 to 5.81) and older (OR 3.80; 95% CI 1.25 to 11.55) women and lower (OR 0.35; 95% CI 0.17 to 0.72) among younger married women. CONCLUSIONS: This study demonstrated U-shaped age-specific genotype profile of carcinogenic HPV prevalence, indicating that public health providers should focus on developing exit strategies for the cervical cancer screening programme in Estonia with a possible extension of HPV testing beyond the current screening age of 65 years. Generalisability of the findings of this study may be affected by the low response rate. | en |
dc.format.extent | 1147472 | - |
dc.language.iso | eng | - |
dc.relation.ispartof | BMJ Open | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.subject | Female | - |
dc.subject | Humans | - |
dc.subject | Uterine Cervical Neoplasms/epidemiology | - |
dc.subject | Papillomavirus Infections/prevention & control | - |
dc.subject | Human Papillomavirus Viruses | - |
dc.subject | Cross-Sectional Studies | - |
dc.subject | Estonia/epidemiology | - |
dc.subject | Carcinogens | - |
dc.subject | Prevalence | - |
dc.subject | Early Detection of Cancer/adverse effects | - |
dc.subject | Genotype | - |
dc.subject | Papillomaviridae/genetics | - |
dc.subject | Papillomavirus Vaccines | - |
dc.subject | Age Factors | - |
dc.subject | sexual medicine | - |
dc.subject | epidemiology | - |
dc.subject | reproductive medicine | - |
dc.subject | public health | - |
dc.subject | 3.2 Clinical medicine | - |
dc.subject | 1.1. Scientific article indexed in Web of Science and/or Scopus database | - |
dc.subject | General Medicine | - |
dc.subject | SDG 3 - Good Health and Well-being | - |
dc.title | Age-specific and genotype-specific carcinogenic human papillomavirus prevalence in a country with a high cervical cancer burden : results of a cross-sectional study in Estonia | en |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article | - |
dc.identifier.doi | 10.1136/bmjopen-2022-069558 | - |
dc.contributor.institution | Institute of Public Health | - |
dc.contributor.institution | Department of Public Health and Epidemiology | - |
dc.contributor.institution | Department of Obstetrics and Gynaecology | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85160967394&partnerID=8YFLogxK | - |
dc.identifier.url | https://www.mendeley.com/catalogue/02370585-ebc2-3af6-9a0b-8b267d5b113e/ | - |
dc.description.status | Peer reviewed | - |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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