DSpace Community: Īstenošanas struktūrvienība: Mikrobioloģijas un virusoloģijas institūts. Projekta koordinators: Modra Murovska. Projekta īstenošanas laiks: 01.12.2020.-30.11.2023.Īstenošanas struktūrvienība: Mikrobioloģijas un virusoloģijas institūts. Projekta koordinators: Modra Murovska. Projekta īstenošanas laiks: 01.12.2020.-30.11.2023.https://dspace.rsu.lv/jspui/handle/123456789/28862024-03-08T23:39:06Z2024-03-08T23:39:06ZInternational Conference “Autoimmune Diseases: Main Problems and Solutions” (November 9–10, 2023 Riga). Abstract Bookhttps://dspace.rsu.lv/jspui/handle/123456789/149842023-11-24T11:14:00Z2023-11-01T00:00:00ZTitle: International Conference “Autoimmune Diseases: Main Problems and Solutions” (November 9–10, 2023 Riga). Abstract Book
Abstract: Conference is organized by the Rīga Stradiņš University within the frame of the EC Horizon 2020 Framework program project “Reducing networking gaps between Rīga Stradiņš University (RSU) and internationally-leading counterparts in viral infection-induced autoimmunity research (VirA)”. The aim of the Conference is to bring together researchers exploring triggers and mechanisms of autoimmunity, leading to better understanding of chronic diseases and comorbidities in order to deliver precise and early diagnostic and to move towards the development of personalized medicine. The scientific program of the Conference covers different aspects of autoimmunity in plenary lectures, oral presentations and poster sessions. The Conference has attracted about 100 participants from 7 countries.
Description: VirA project Homepage: https://vira-twinning.eu/2023-11-01T00:00:00ZPrediction of discontinuation of structured exercise programme in chronic fatigue syndrome patients.Kujawski, SławomirCossington, JoSłomko, JoannaDawes, HelenStrong, James W. L.Estevez-Lopez, FernandoMurovska, ModraNewton, Julia L.Hodges, LynetteZalewski, Pawełhttps://dspace.rsu.lv/jspui/handle/123456789/72312022-01-19T09:33:04Z2020-10-26T00:00:00ZTitle: Prediction of discontinuation of structured exercise programme in chronic fatigue syndrome patients.
Authors: Kujawski, Sławomir; Cossington, Jo; Słomko, Joanna; Dawes, Helen; Strong, James W. L.; Estevez-Lopez, Fernando; Murovska, Modra; Newton, Julia L.; Hodges, Lynette; Zalewski, Paweł
Abstract: Purpose: The purpose of this study was to assess differences in the physiological profiles of completers vs. non-completers following a structured exercise programme (SEP) and the ability to predict non-completers, which is currently unknown in this group. Methods: Sixty-nine patients met the Fukuda criteria. Patients completed baseline measures assessing fatigue, autonomic nervous system (ANS), cognitive, and cardiovascular function. Thirty-four patients completed a home-based SEP consisting of 10–40 min per day at between 30 and 80% actual HR max. Exercise intensity and time was increased gradually across the 16 weeks and baseline measures were repeated following the SEP. Results: Thirty-five patients discontinued, while 34 completed SEP. For every increase in sympathetic drive for blood pressure control as measured by the taskforce, completion of SEP decreased by a multiple of 0.1. For a 1 millisecond increase in reaction time for the simple reaction time (SRT), the probability for completion of SEP also decreases by a multiple of 0.01. For a one beat HRmax increase, there is a 4% increase in the odds of completing SEP. Conclusion: The more sympathetic drive in the control of blood vessels, the longer the reaction time on simple visual stimuli and the lower the HRmax during physical exercise, then the lower the chance of SEP completion in ME/CFS.2020-10-26T00:00:00ZAutonomic phenotypes in chronic fatigue syndrome (CFS) are associated with illness severity: A cluster analysisSlomko, JoannaEstevez-Lopez, FernandoKujawski, SławomirZawadka-Kunikowska, MonikaTafil-Klawe, MałgorzataKlawe, Jacek J.Morten, Karl J.Szrajda, JustynaMurovska, ModraNewton, Julia L.Zalewski, Pawełhttps://dspace.rsu.lv/jspui/handle/123456789/72302022-01-19T09:28:54Z2020-08-05T00:00:00ZTitle: Autonomic phenotypes in chronic fatigue syndrome (CFS) are associated with illness severity: A cluster analysis
Authors: Slomko, Joanna; Estevez-Lopez, Fernando; Kujawski, Sławomir; Zawadka-Kunikowska, Monika; Tafil-Klawe, Małgorzata; Klawe, Jacek J.; Morten, Karl J.; Szrajda, Justyna; Murovska, Modra; Newton, Julia L.; Zalewski, Paweł
Abstract: In this study we set out to define the characteristics of autonomic subgroups of patients with Chronic Fatigue Syndrome (CFS). The study included 131 patients with CFS (Fukuda criteria). Participants completed the following screening symptom assessment tools: Chalder Fatigue Scale, Fatigue Impact Scale, Fatigue Severity Scale, Epworth Sleepiness Scales, the self-reported Composite Autonomic Symptom Scale. Autonomic parameters were measured at rest with a Task Force Monitor (CNS Systems) and arterial stiffness using an Arteriograph (TensioMed Kft.). Principal axis factor analysis yielded four factors: fatigue, subjective and objective autonomic dysfunction and arterial stiffness. Using cluster analyses, these factors were grouped in four autonomic profiles: 34% of patients had sympathetic symptoms with dysautonomia, 5% sympathetic alone, 21% parasympathetic and 40% had issues with sympathovagal balance. Those with a sympathetic-dysautonomia phenotype were associated with more severe disease, reported greater subjective autonomic symptoms with sympathetic over-modulation and had the lowest quality of life. The highest quality of life was observed in the balance subtype where subjects were the youngest, had lower levels of fatigue and the lowest values for arterial stiffness. Future studies will aim to design autonomic profile-specific treatment interventions to determine links between autonomic phenotypes CFS and a specific treatment.2020-08-05T00:00:00ZManagement of a primary malignant melanoma of uterine cervix stage IVA patient with radical surgery and adjuvant oncolytic virus Rigvir(R) therapy: A case report.Pumpure, ElizabeteDručka, EvaKigitoviča, DanaMeškauskas, RaimundasIsajevs, SergejsNemiro, InetaRasa, AgnijaOlmane, EvijaZablocka, TatjanaAlberts, PēterisDoniņa, Simonahttps://dspace.rsu.lv/jspui/handle/123456789/72292022-10-11T06:20:02Z2020-05-22T00:00:00ZTitle: Management of a primary malignant melanoma of uterine cervix stage IVA patient with radical surgery and adjuvant oncolytic virus Rigvir(R) therapy: A case report.
Authors: Pumpure, Elizabete; Dručka, Eva; Kigitoviča, Dana; Meškauskas, Raimundas; Isajevs, Sergejs; Nemiro, Ineta; Rasa, Agnija; Olmane, Evija; Zablocka, Tatjana; Alberts, Pēteris; Doniņa, Simona
Abstract: Primary malignant melanoma of the uterine cervix is a rare disease with poor prognosis and high recurrence rate. We used Rigvir® as adjuvant therapy for a stage IVA patient. Tolerability, overall and progression-free survival are good.2020-05-22T00:00:00Z