Amygdala Nuclei Atrophy in Cognitive Impairment and Dementia : Insights from High-Resolution Magnetic Resonance Imaging

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dc.contributor.authorPeiseniece, Evija
dc.contributor.authorZdanovskis, Nauris
dc.contributor.authorŠneidere, Kristīne
dc.contributor.authorKostiks, Andrejs
dc.contributor.authorKarelis, Guntis
dc.contributor.authorPlatkājis, Ardis
dc.contributor.authorStepens, Ainārs
dc.contributor.institutionDepartment of Radiology
dc.contributor.institutionInstitute of Public Health
dc.contributor.institutionDepartment of Health Psychology and Paedagogy
dc.contributor.institutionDepartment of Infectology
dc.date.accessioned2025-01-30T11:55:02Z
dc.date.available2025-01-30T11:55:02Z
dc.date.issued2025-01-15
dc.descriptionPublisher Copyright: © 2025 by the authors.
dc.description.abstractBackground and Objectives: Cognitive impairment affects memory, reasoning, and problem-solving, with early detection being critical for effective management. The amygdala, a key structure in emotional processing and memory, may play a pivotal role in detecting cognitive decline. This study examines differences in amygdala nuclei volumes in patients with varying levels of cognitive performance to evaluate its potential as a biomarker.  Material and methods: This cross-sectional study of 35 participants was conducted and classified into three groups: the normal (≥26), moderate (15-25), and low (≤14) cognitive performance groups based on the Montreal Cognitive Assessment (MoCA) scores. High-resolution magnetic resonance imaging at 3.0 T scanner was used to assess amygdala nuclei volumes.  Results: Significant amygdala atrophy was observed in multiple amygdala nuclei across cognitive performance groups, with more pronounced changes in the low-performance group. The right hemisphere nuclei, including the lateral and basal nuclei, showed more significant differences, indicating their sensitivity to cognitive decline.  Conclusions: This study highlights the potential of amygdala nuclei atrophy as a biomarker for cognitive impairment. Additional research with larger sample sizes and longitudinal designs is needed to confirm these findings and determine their diagnostic value.en
dc.description.statusPeer reviewed
dc.format.extent1740961
dc.identifier.citationPeiseniece, E, Zdanovskis, N, Šneidere, K, Kostiks, A, Karelis, G, Platkājis, A & Stepens, A 2025, 'Amygdala Nuclei Atrophy in Cognitive Impairment and Dementia : Insights from High-Resolution Magnetic Resonance Imaging', Medicina (Kaunas, Lithuania), vol. 61, no. 1, 130. https://doi.org/10.3390/medicina61010130
dc.identifier.doi10.3390/medicina61010130
dc.identifier.issn1010-660X
dc.identifier.otherPubMedCentral: PMC11766737
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/17062
dc.identifier.urlhttps://www-webofscience-com.db.rsu.lv/wos/alldb/full-record/MEDLINE:39859112
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85215798421&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofMedicina (Kaunas, Lithuania)
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHumans
dc.subjectAmygdala/diagnostic imaging
dc.subjectMale
dc.subjectFemale
dc.subjectMagnetic Resonance Imaging/methods
dc.subjectCross-Sectional Studies
dc.subjectCognitive Dysfunction/etiology
dc.subjectAtrophy
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectDementia/diagnostic imaging
dc.subjectNeuropsychological Tests
dc.subjectAged, 80 and over
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.titleAmygdala Nuclei Atrophy in Cognitive Impairment and Dementia : Insights from High-Resolution Magnetic Resonance Imagingen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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