Genetic architecture of the APM1 gene and its influence on adiponectin plasma levels and parameters of the metabolic syndrome in 1,727 healthy Caucasians

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dc.contributor.authorHeid, Iris M.
dc.contributor.authorWagner, Stefanie A.
dc.contributor.authorGohlke, Henning
dc.contributor.authorIglseder, Bernhard
dc.contributor.authorCip, Paula
dc.contributor.authorLadurner, Günther
dc.contributor.authorMackevics, Vitolds
dc.contributor.authorIllig, Thomas
dc.contributor.authorKronenberg, Florian
dc.contributor.authorPaulweber, Bernhard
dc.date.accessioned2021-09-17T06:40:01Z
dc.date.available2021-09-17T06:40:01Z
dc.date.issued2006-02
dc.descriptionCopyright: Copyright 2008 Elsevier B.V., All rights reserved.
dc.description.abstractThe associations of the adiponectin (APM1) gene with parameters of the metabolic syndrome are inconsistent. We performed a systematic investigation based on fine-mapped single nucleotide polymorphisms (SNPs) highlighting the genetic architecture and their role in modulating adiponectin plasma concentrations in a particularly healthy population of 1,727 Caucasians avoiding secondary effects from disease processes. Genotyping 53 SNPs (average spacing of 0.7 kb) in the APM1 gene region in 81 Caucasians revealed a two-block linkage disequilibrium (LD) structure and enabled comprehensive tag SNP selection. We found particularly strong associations with adiponectin concentrations for 11 of the 15 tag SNPs in the 1,727 subjects (five P values <0.0001). Haplotype analysis provided a thorough differentiation of adiponectin concentrations with 9 of 17 haplotypes showing significant associations (three P values <0.0001). No significant association was found for any SNP with the parameters of the metabolic syndrome. We observed a two-block LD structure of APM1 pointing toward at least two independent association signals, one including the promoter SNPs and a second spanning the relevant exons. Our data on a large number of healthy subjects suggest a clear modulation of adiponectin concentrations by variants of APM1, which are not merely a concomitant effect in the course of type 2 diabetes or coronary artery disease.en
dc.description.statusPeer reviewed
dc.format.extent10
dc.format.extent285007
dc.identifier.citationHeid, I M, Wagner, S A, Gohlke, H, Iglseder, B, Cip, P, Ladurner, G, Mackevics, V, Illig, T, Kronenberg, F & Paulweber, B 2006, 'Genetic architecture of the APM1 gene and its influence on adiponectin plasma levels and parameters of the metabolic syndrome in 1,727 healthy Caucasians', Diabetes, vol. 55, no. 2, pp. 375-384. https://doi.org/10.2337/diabetes.55.02.06.db05-0747
dc.identifier.doi10.2337/diabetes.55.02.06.db05-0747
dc.identifier.issn0012-1797
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/6378
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=33644751829&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofDiabetes
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject3.1 Basic medicine
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectInternal Medicine
dc.subjectEndocrinology, Diabetes and Metabolism
dc.subjectSDG 3 - Good Health and Well-being
dc.titleGenetic architecture of the APM1 gene and its influence on adiponectin plasma levels and parameters of the metabolic syndrome in 1,727 healthy Caucasiansen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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