Cytokines, Proliferation Markers, Antimicrobial Factors and Neuropeptide-Containing Innervation in Human Nasal Mucosa after Rhinoseptoplasty Procedure

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dc.contributor.authorPodlesnaja, Marija
dc.contributor.authorPilmane, Mara
dc.contributor.authorSumeraga, Gunta
dc.contributor.institutionInstitute of Anatomy and Anthropology
dc.date.accessioned2021-05-17T06:50:01Z
dc.date.available2021-05-17T06:50:01Z
dc.date.issued2021-04-21
dc.description.abstractThe nasal cavity lined by nasal mucosa, is a significant part of respiratory system of human. However, there are no studies aimed to detect a molecular phenotype of healthy and normal functioning nasal mucosa, obtained after rhinoseptoplasty procedure, to understand its physiology and growth and inflammation processes. Thus, our aim is to identify human healthy nasal mucosa cytokines, neuropeptide-containing innervation and cell proliferation markers to form a control group for further tissue investigation of human nasal polyposis as the next step of our research. The study included surgery materials from 17 healthy humans. Biotin-streptavidin immunohistochemistry was performed for detection of tissue PGP9.5, Ki-67, β-Defensin 2, IL-1, IL-4, IL-6, IL-7, IL-8, IL-10, IL-12. Results were evaluated semi-quantitatively and by Friedman ANOVA and Spearman rang correlation tests. All factors were more widely expressed by superficial epithelium than by glandular one. Abundance of ILs-8, -10 and -12 positive cells was detected in comparison with moderate to numerous distributions of IL-1, IL-6 and β-Defensin 2. Moderate number of PGP 9.5-containing nerve fibers and only few to moderate Ki-67 positive cells were found in healthy nasal mucosa. We revealed statistically significant difference between Ki-67 and ILs-4, -6, -7, -8, -10, -12 both in healthy nasal mucosa superficial and glandular epithelium. From nasal epithelia, commonly the surface one displays more cytokines and β-Defensin 2 in comparison to the glandular one. Numerous to abundant expression of ILs-4, -6, -7, -8, -10, -12 and β-Defensin 2 in nasal superficial and glandular epithelia proves probably these factors' role into the common immune response of tissue and stimulation of immune cell differentiation.en
dc.description.statusPeer reviewed
dc.format.extent11
dc.format.extent24127591
dc.identifier.citationPodlesnaja, M, Pilmane, M & Sumeraga, G 2021, 'Cytokines, Proliferation Markers, Antimicrobial Factors and Neuropeptide-Containing Innervation in Human Nasal Mucosa after Rhinoseptoplasty Procedure', Medical sciences (Basel, Switzerland), vol. 9, no. 2, 25, pp. 25. https://doi.org/10.3390/medsci9020025
dc.identifier.doi10.3390/medsci9020025
dc.identifier.issn2076-3271
dc.identifier.otherMendeley: dfe3b84a-c887-3bf6-b624-26f3a413fa30
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/4301
dc.identifier.urlhttps://www.mendeley.com/catalogue/dfe3b84a-c887-3bf6-b624-26f3a413fa30/
dc.language.isoeng
dc.relation.ispartofMedical sciences (Basel, Switzerland)
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectnose
dc.subjectmucosa
dc.subjecthealthy
dc.subjecthuman
dc.subjectcytokines
dc.subjectepithelium
dc.subjectinnervation
dc.subject3.1 Basic medicine
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectSDG 3 - Good Health and Well-being
dc.titleCytokines, Proliferation Markers, Antimicrobial Factors and Neuropeptide-Containing Innervation in Human Nasal Mucosa after Rhinoseptoplasty Procedureen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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