Development of Composite Sponge Scaffolds Based on Carrageenan (CRG) and Cerium Oxide Nanoparticles (CeO2 NPs) for Hemostatic Applications

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dc.contributor.authorKimia, Alizadeh
dc.contributor.authorDezvare, Yasaman
dc.contributor.authorKamyab, Shirin
dc.contributor.authorAmirian , Jhaleh
dc.contributor.authorBrangule, Agnese
dc.contributor.authorBandere, Dace
dc.contributor.institutionDepartment of Pharmaceutical Chemistry
dc.date.accessioned2023-10-05T11:55:01Z
dc.date.available2023-10-05T11:55:01Z
dc.date.issued2023-09-04
dc.descriptionPublisher Copyright: Ā© 2023 by the authors.
dc.description.abstractIn this study, a novel absorbable hemostatic agent was developed using carrageenan (CRG) as a natural polymer and cerium oxide nanoparticles (CeO2 NPs). CRG-CeO2-0.5 and CRG-CeO2-1 composites were prepared by compositing CeO2 to CRG + CeO2 at a weight ratio of 0.5:100 and 1:100, respectively. The physicochemical and structural properties of these compounds were studied and compared with pristine CRG. Upon incorporation of CeO2 nanoparticles into the CRG matrix, significant reductions in hydrogel degradation were observed. In addition, it was noted that CRG-CeO2 exhibited better antibacterial and hemostatic properties than CRG hydrogel without CeO2 NPs. The biocompatibility of the materials was tested using the NIH 3T3 cell line, and all samples were found to be nontoxic. Particularly, CRG-CeO2-1 demonstrated superior hemostatic effects, biocompatibility, and a lower degradation rate since more CeO2 NPs were present in the CRG matrix. Therefore, CRG-CeO2-1 has the potential to be used as a hemostatic agent and wound dressing.en
dc.description.statusPeer reviewed
dc.format.extent17
dc.format.extent11283618
dc.identifier.citationKimia, A, Dezvare, Y, Kamyab, S, Amirian , J, Brangule, A & Bandere, D 2023, 'Development of Composite Sponge Scaffolds Based on Carrageenan (CRG) and Cerium Oxide Nanoparticles (CeO2 NPs) for Hemostatic Applications', Biomimetics, vol. 8, no. 5, 409. https://doi.org/10.3390/biomimetics8050409
dc.identifier.doi10.3390/biomimetics8050409
dc.identifier.issn2313-7673
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/14909
dc.identifier.urlhttps://www.mdpi.com/2313-7673/8/5/409
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85172175275&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofBiomimetics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcarrageenan (CRG)
dc.subjectcerium oxide (CeO2);
dc.subjectnanoparticles (NPs)
dc.subjectcomposite
dc.subjectAntibacterial properties
dc.subjecthemostatic effect
dc.subject1.6 Biological sciences
dc.subject2.10 Nano-technology
dc.subject2.5 Materials engineering
dc.subject2.11 Other engineering and technologies
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.titleDevelopment of Composite Sponge Scaffolds Based on Carrageenan (CRG) and Cerium Oxide Nanoparticles (CeO2 NPs) for Hemostatic Applicationsen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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