Apoptosis and MMP-2, TIMP-2 expression in cleft lip and palate

Simple item page
dc.contributor.authorSmane, Liene
dc.contributor.authorPilmane, Mara
dc.contributor.authorAkota, Ilze
dc.contributor.institutionInstitute of Anatomy and Anthropology
dc.contributor.institutionDepartment of Morphology
dc.contributor.institutionRīga Stradiņš University
dc.date.accessioned2021-04-28T06:30:01Z
dc.date.available2021-04-28T06:30:01Z
dc.date.issued2013
dc.description.abstractAim of our study was complex detection of appearance and distribution of specific signalling proteins and apoptosis in facial tissue of children with complete bilateral cleft lip and palate (CBCLP). MATERIALS AND METHODS. Nineteen CBCLP patients and 11 unaffected subjects were involved in this study. All the tissue samples were proceeded for detection of matrix metalloproteinase-2 (MMP-2), tissue inhibitor of matrix metalloproteinase-2 (TIMP-2), and apoptosis. The intensity of immunostaining was graded semi-quantitatively. Results of the terminal deoxynucleotidyl transferase mediated dUTP nick-end labeling (TUNEL) method were obtained by counting apoptosis positive cells in five unintentionally chosen fields of vision. Groups were compared using the Mann-Whitney test. RESULTS. TUNEL-positive oral epithelial cells were significantly increased in the control group when compared with the CBCLP group. Connective tissue cells have a statistically significant lower expression of TIMP-2 in the control group compared to the CBCLP group. CONCLUSIONS. TIMP-2 positive connective tissue cells increasingly found in oral mucosa lamina propria proves the decrease of local apoptosis in CLP patients. Prominent expression of MMP-2 in cleft affected soft tissue indicates a possible increase of tissue remodelling.en
dc.description.statusPeer reviewed
dc.format.extent6
dc.format.extent516766
dc.identifier.citationSmane, L, Pilmane, M & Akota, I 2013, 'Apoptosis and MMP-2, TIMP-2 expression in cleft lip and palate', Stomatologija / issued by public institution "Odontologijos studija" ... [et al.], vol. 15, no. 4, pp. 129-134.
dc.identifier.issn1392-8589
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/3946
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84922008539&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofStomatologija / issued by public institution "Odontologijos studija" ... [et al.]
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectsignalling proteins
dc.subjectapoptosis
dc.subjectcleft lip and palate
dc.subjectchildren
dc.subject3.1 Basic medicine
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral Medicine
dc.titleApoptosis and MMP-2, TIMP-2 expression in cleft lip and palateen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Apoptosis_and_MMP_2_TIMP_2_expression_in_cleft_lip_and_palate.pdf
Size:
504.65 KB
Format:
Adobe Portable Document Format
Download

Collections

Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure