Antimicrobial peptides and interleukins in cleft soft palate

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dc.contributor.authorDeņisova, Arina
dc.contributor.authorPilmane, Māra
dc.contributor.authorKažoka, Dzintra
dc.contributor.institutionInstitute of Anatomy and Anthropology
dc.date.accessioned2023-08-02T14:10:02Z
dc.date.available2023-08-02T14:10:02Z
dc.date.issued2023-07-02
dc.descriptionPublisher Copyright: © 2023 by the authors.
dc.description.abstractCleft palate is one of the most common and well-studied congenital anomalies; however, the role of protective tissue factors in its pathophysiology is still debated. The aim of our study was to evaluate interleukin and antimicrobial peptide appearance and distribution in cleft palate. Eight soft palate samples were obtained during veloplasty procedures. Immunohistochemical staining was applied to detect HBD-2-, HBD-3-, HBD-4-, LL-37-, IL-10-, and CD-163-positive cells via light microscopy. For statistical evaluation, the Mann–Whitney U test and Spearman’s rank correlation coefficient were used. A significant difference between study groups was observed for HBD-2 and IL-10 in epithelial and connective tissue as well as HBD-4 in connective tissue. The number of HBD-3- positive cells was moderate in the patients, and few were observed in the controls. The number of LL-37-positive cells varied from a moderate amount to a numerous amount in both study groups, whilst CD-163 marked a moderate number of positive cells in patients, and a few-to-moderate amount was observed in the controls. Numerous correlations between studied factors were revealed in cleft tissues. The increase in antimicrobial peptides HBD-2 and HBD-4 and anti-inflammatory cytokine IL-10 suggested a wide compensatory elevation of the local immune system against cleft-raised tissue changes. The correlations between the studied factors (HBD-2, HBD-3, HBD-4, LL-37, and IL-10) proved the synergistic involvement of common local defense factors in postnatal cleft palate morphopathogenesis.en
dc.description.statusPeer reviewed
dc.format.extent15
dc.format.extent26575459
dc.identifier.citationDeņisova, A, Pilmane, M & Kažoka, D 2023, 'Antimicrobial peptides and interleukins in cleft soft palate', Children, vol. 10, no. 7, 1162, pp. 1-15. https://doi.org/10.3390/children10071162
dc.identifier.doi10.3390/children10071162
dc.identifier.issn2227-9067
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/14271
dc.identifier.urlhttps://www.webofscience.com/wos/alldb/full-record/MEDLINE:37508659
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85166283597&partnerID=8YFLogxK
dc.identifier.urlhttps://doi.org/10.3390/children10071162
dc.language.isoeng
dc.relation.ispartofChildren
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcleft palate
dc.subjectinterleukin 10
dc.subjecthuman beta defensins
dc.subjectcathelicidin
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.titleAntimicrobial peptides and interleukins in cleft soft palateen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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