Contactless photoplethysmography for assessment of small fiber neuropathy

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dc.contributor.authorMarcinkevics, Zbignevs
dc.contributor.authorRubins, Uldis
dc.contributor.authorAglinska, Alise
dc.contributor.authorLogina, Inara
dc.contributor.authorGlazunovs, Dmitrijs
dc.contributor.authorGrabovskis, Andris
dc.contributor.institutionDepartment of Neurology and Neurosurgery
dc.date.accessioned2023-10-20T08:40:01Z
dc.date.available2023-10-20T08:40:01Z
dc.date.issued2023-08-23
dc.descriptionPublisher Copyright: Copyright © 2023 Marcinkevics, Rubins, Aglinska, Logina, Glazunovs and Grabovskis.
dc.description.abstractChronic pain is a prevalent condition affecting approximately one-fifth of the global population, with significant impacts on quality of life and work productivity. Small fiber neuropathies are a common cause of chronic pain, and current diagnostic methods rely on subjective self-assessment or invasive skin biopsies, highlighting the need for objective noninvasive assessment methods. The study aims to develop a modular prototype of a contactless photoplethysmography system with three spectral bands (420, 540, and 800 nm) and evaluate its potential for assessing peripheral neuropathy patients via a skin topical heating test and spectral analyses of cutaneous flowmotions. The foot topical skin heating test was conducted on thirty volunteers, including fifteen healthy subjects and fifteen neuropathic patients. Four cutaneous nerve fiber characterizing parameters were evaluated at different wavelengths, including vasomotor response trend, flare area, flare intensity index, and the spectral power of cutaneous flowmotions. The results show that neuropathic patients had significantly lower vasomotor response (50%), flare area (63%), flare intensity index (19%), and neurogenic component (54%) of cutaneous flowmotions compared to the control group, independent of photoplethysmography spectral band. An absolute value of perfusion was 20%–30% higher in the 420 nm band. Imaging photoplethysmography shows potential as a cost-effective alternative for objective and non-invasive assessment of neuropathic patients, but further research is needed to enhance photoplethysmography signal quality and establish diagnostic criteria.en
dc.description.statusPeer reviewed
dc.format.extent16
dc.format.extent3061987
dc.identifier.citationMarcinkevics, Z, Rubins, U, Aglinska, A, Logina, I, Glazunovs, D & Grabovskis, A 2023, 'Contactless photoplethysmography for assessment of small fiber neuropathy', Frontiers in Physiology, vol. 14, 1180288, pp. 01 -16. https://doi.org/10.3389/fphys.2023.1180288
dc.identifier.doi10.3389/fphys.2023.1180288
dc.identifier.issn1664-042X
dc.identifier.otherMendeley: 19dc898a-0d34-3179-8646-8bff43f012ce
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/14919
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85171382456&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofFrontiers in Physiology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAxon reflex flare
dc.subjectCutaneous vasomotion
dc.subjectImaging photoplethysmography
dc.subjectOptical diagnostic imaging
dc.subjectRemote photoplethysmography
dc.subjectSmall fiber neuropathy
dc.subjectTopical heating
dc.subjectVasomotor responses
dc.subject3.1 Basic medicine
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.titleContactless photoplethysmography for assessment of small fiber neuropathyen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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