Signalling molecules in jaw bones and gingival tissues of patients with Class II and Class III dentofacial deformities

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dc.contributor.authorJankovska, Iveta
dc.contributor.authorPilmane, Mara
dc.contributor.authorUrtane, Ilga
dc.contributor.institutionRīga Stradiņš University
dc.contributor.institutionDepartment of Morphology
dc.contributor.institutionInstitute of Anatomy and Anthropology
dc.date.accessioned2021-04-22T13:50:01Z
dc.date.available2021-04-22T13:50:01Z
dc.date.issued2017
dc.description.abstractOBJECTIVES: To detect signalling molecule specificities in jaw bone growth zones in skeletal class II and class III patients and compare them to those of a control group. MATERIAL AND METHODS: Twenty skeletal Class II and 20 skeletal Class III patients who underwent orthognathic surgery treatment were in the study group and five skeletal Class I patients who had impacted third molars extracted were in the control group. During the orthognathic surgery, tissue samples were taken from the tuber maxillae, ramus mandibulae anterior and posterior part together with mucosa from the gingival transitory fold in the second molar region of the lower jaw. The samples were stained to detect TGF-β, BMP2/4, FGFR1, VEGF, OC, OP and MMP2 expression. The distributions of these factors were assessed semiquantitatively. RESULTS: We observed significant expression of TGF-β, BMP2/4, OC and OP in the bone tissue of the study group. FGFR1 expression was more pronounced only in mucosa. VEGF and MMP2 were found only in some tissue samples. More apoptotic cells were observed in the bone tissue and soft tissue of the control patients than in those of the skeletal Class II and Class III patients, in which apoptotic cell frequencies were relatively equal. CONCLUSION: From bone tissue in tuber maxillae region the greater TGF-β and BMP2/4 expression is seen in Class III and control groups, comparing to Class II. In ramus mandibulae anterior part the expression of significant factors in bone tissue growth (TGF-β un BMP2/4) is higher in the control group and Class II patients, while in ramus mandibulae posterior part higher expression of TGF-β and BMP2/4 is in Class III patients, comparing to Class II, which indicates to a preserved growth potential in these jaw bone regions. More active bone extracellular matrix protein (osteocalcin and osteopontin) expression in tuber maxillae region both in class II and class III patient groups and different expression in ramus mandibulae anterior part, prove to the bone mineralization and metabolism activity changes, which, perhaps, characterize just these dentofacial deformations.en
dc.description.statusPeer reviewed
dc.format.extent7
dc.format.extent783884
dc.identifier.citationJankovska, I, Pilmane, M & Urtane, I 2017, 'Signalling molecules in jaw bones and gingival tissues of patients with Class II and Class III dentofacial deformities', Stomatologija, vol. 19, no. 3, pp. 71-77.
dc.identifier.issn1392-8589
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/3908
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85051927684&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofStomatologija
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectorthognathic surgery
dc.subjectbone
dc.subjectsignalling molecules
dc.subjectimmunohistochemistry
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral Medicine
dc.titleSignalling molecules in jaw bones and gingival tissues of patients with Class II and Class III dentofacial deformitiesen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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