Expresión de IRF6, RYK y PAX9 en el tejido facial de niños con paladar fisurado

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dc.contributor.authorSmane, Liene
dc.contributor.authorPilmane, Mara
dc.contributor.institutionInstitute of Anatomy and Anthropology
dc.contributor.institutionDepartment of Morphology
dc.date.accessioned2021-04-28T11:50:01Z
dc.date.available2021-04-28T11:50:01Z
dc.date.issued2015-06-01
dc.descriptionPublisher Copyright: © 2015, Universidad de la Frontera. All rights reserved.
dc.description.abstractCleft lip and palate (CLP) is a congenital anomaly characterized by the inappropriate fusion of the upper lip, alveolus, and secondary palate. This study investigated whether expression of interferon regulatory fac tor 6 (IRF6), receptor-like tyrosine kinase (RYK), and paired-box 9 (PAX9), which are essential for the normal development and morphogenesis of craniofacial structures, is dysregulated in children with CLP. Oral mucosa tissue samples were obtained from patients with complete bilateral (CB) CLP (n= 19) during corrective plastic surgery and unaffected control subjects (n= 7). IRF6, RYK, and PAX9 expression was assessed by immunohistochemistry, and data were analyzed with the Mann-Whitney test. In patients, IRF6 immunoreactivity in the connective tissue was moderate to high, but the overall number of IRF6-positive oral epithelial cells was lower than that in controls (z= -3.41; P= 0.01). RYK expression was observed only sporadically in the oral epithelium of 4 patients, in contrast to the control group (z= -3.75; P< 0.001). PAX9-positive epithelial cells were present in low to moderate numbers in patients with CBCLP, while an abundance of these cells was observed in the basal layer of the oral epithelium in controls (z= -3.60; P<0.001). IRF6 is the main connective tissue regulatory factor in CBCLP, and its low level of expression in the oral epithelium suggests a reduced potential for epitheliocyte differentiation, while low PAX9 and RYK expression may explain the decreased cell migration and cleft remodeling in CBCLP.en
dc.description.statusPeer reviewed
dc.format.extent6
dc.format.extent160347
dc.identifier.citationSmane, L & Pilmane, M 2015, 'Expresión de IRF6, RYK y PAX9 en el tejido facial de niños con paladar fisurado', International Journal of Morphology, vol. 33, no. 2, pp. 647-652. https://doi.org/10.4067/S0717-95022015000200037
dc.identifier.doi10.4067/S0717-95022015000200037
dc.identifier.issn0717-9367
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/3976
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84939497379&partnerID=8YFLogxK
dc.language.isospa
dc.relation.ispartofInternational Journal of Morphology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCleft palate
dc.subjectInterferon regulatory factor 6
dc.subjectPaired box gene 9
dc.subjectReceptor-like tyrosine kinase
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectAnatomy
dc.titleExpresión de IRF6, RYK y PAX9 en el tejido facial de niños con paladar fisuradoes
dc.title.alternativeIRF6, RYK, and PAX9 expression in facial tissue of children with cleft palateen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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