Chromothripsis and progression-free survival in metastatic colorectal cancer

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dc.contributor.authorSkuja, Elina
dc.contributor.authorKalniete, Dagnija
dc.contributor.authorNakazawa-Miklaševiča, Miki
dc.contributor.authorDaneberga, Zanda
dc.contributor.authorAbolins, Arnis
dc.contributor.authorPurkalne, Gunta
dc.contributor.authorMiklasevics, Edvins
dc.contributor.institutionOnkoloģijas institūts
dc.date.accessioned2021-09-07T11:25:01Z
dc.date.available2021-09-07T11:25:01Z
dc.date.issued2017-02
dc.description.abstractMetastatic dissemination of the primary tumor is the major cause of death in colorectal cancer (CRC) patients. Multiple chromosomal breaks and chromothripsis, a phenomenon involving multiple chromosomal fragmentations occurring in a single catastrophic event, are associated with cancer genesis, progression and developing of metastases. The aim of this study was to evaluate the effect of chromothripsis and total breakpoint count (breakpoint instability index) on progression-free survival (PFS). A total of 19 patients with metastatic CRC (mCRC) receiving FOLFOX first‑line palliative chemotherapy between August, 2011 and October, 2012 were selected for this study. The results indicated that the highest breakpoint count was observed in chromosomes 1, 2 and 6. Chromothripsis was detected in 52.6% of the study patients. Furthermore, chromothripsis was associated with an increased median PFS (mPFS; 14 vs. 8 months, respectively; P=0.03), but an association with overall survival was not identified. The present study demonstrated that chromothripsis affected CRC patient survival, suggesting a role for this event as a prognostic and predictive marker in mCRC treatment.en
dc.description.statusPeer reviewed
dc.format.extent5
dc.format.extent928108
dc.identifier.citationSkuja, E, Kalniete, D, Nakazawa-Miklaševiča, M, Daneberga, Z, Abolins, A, Purkalne, G & Miklasevics, E 2017, 'Chromothripsis and progression-free survival in metastatic colorectal cancer', Molecular and Clinical Oncology, vol. 6, no. 2, pp. 182-186. https://doi.org/10.3892/mco.2017.1123
dc.identifier.doi10.3892/mco.2017.1123
dc.identifier.issn2049-9450
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/6224
dc.identifier.urlhttps://www-webofscience-com.db.rsu.lv/wos/woscc/full-record/WOS:000453171000008
dc.language.isoeng
dc.relation.ispartofMolecular and Clinical Oncology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectmetastatic colorectal cancer
dc.subjectchromothripsis
dc.subjectbreakpoint instability index
dc.subjectprogression-free survival
dc.subject3.2 Clinical medicine
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectSDG 3 - Good Health and Well-being
dc.titleChromothripsis and progression-free survival in metastatic colorectal canceren
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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