The expression of cytokines and β -defensin 2, - 3, -4 in rabbit bone tissue after hydroxyapatite (HAp), α- Tricalcium phosphate (α-TCP) and polymethylmethacrylate (PMMA) implantation
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2012
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Abstract
Bone loss induced by inflammation is one of the complications after biomaterial implantation. There is no much data on expression of cytokines and defensins into the bone tissue around the implants in literature. The aim of this work was to investigate the distribution and appearance of interleukin (IL)-1, IL-6, IL-8, IL-10 and (β - defensin (BD)-2, BD-3, BD-4 after the implantation of different biomaterials. Bone developing zones, signs of bone-implant contact and low expression of pro-inflammatory cytokine IL-1, IL-6 and anti-inflammatory cytokine IL-10 in experimental tissue with pure HAp and unburned HAp implants indicate a potential advantage of this material in terms of its biocompatibility over the other materials used in our study.
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3.1 Basic medicine, 3.2 Clinical medicine, 2.5 Materials engineering, 2.6 Medical engineering, 3.1. Articles or chapters in proceedings/scientific books indexed in Web of Science and/or Scopus database, General Materials Science, General Engineering
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Vamze, J, Pilmane, M & Skagers, A 2012, 'The expression of cytokines and β -defensin 2, - 3, -4 in rabbit bone tissue after hydroxyapatite (HAp), α- Tricalcium phosphate (α-TCP) and polymethylmethacrylate (PMMA) implantation', Paper presented at International Conference "Functional Materials and Nanotechnologies" (FM &NT-2012), Riga, Latvia, 17/04/12 - 20/04/12. https://doi.org/10.1088/1757-899X/38/1/012025
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