Diagnostic markers for early sepsis diagnosis in children with systemic inflammatory response syndrome

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dc.contributor.authorPavare, Jana
dc.contributor.authorGrope, Ilze
dc.contributor.authorKalnins, Imants
dc.contributor.authorGardovska, Dace
dc.contributor.institutionRīga Stradiņš University
dc.date.accessioned2021-12-02T11:05:01Z
dc.date.available2021-12-02T11:05:01Z
dc.date.issued2009
dc.description.abstractSepsis caused by infection remains a major cause of mortality among children. One of the main reasons for high sepsis mortality rates is the inability to obtain early diagnosis. Sensitive and specific biomarkers are greatly needed in rapid diagnosis of sepsis. The main aim of study was to investigate the ability of high-mobility group box-1 protein (HMGB1), lipopolysaccharide-binding protein (LBP), Interleukin-6 (IL-6), procalcitonin (PCT) and C reactive protein (CRP) to differentiate sepsis patients. Eighty-four children with Systemic Inflammatory Response Syndrome (SIRS) were included in the prospective study. Sepsis was recognised in 23% (n = 19) of them. LBP, IL-6, CRP and PCT levels were significantly higher among the sepsis group (P < 0.05). HMGB1 levels in the sepsis patients did not significantly differ from SIRS patients. In ROC analysis in sepsis patients, identification markers LBP, IL6 and CRP performed quite similarly (P < 0.001), with the best result being for IL6. Our data suggest that in early sepsis diagnosis in children, LBP, IL-6, PCT and CRP are probably the superior diagnostic markers, with the best performance by IL6. LBP and IL-6 are superior markers for sepsis patients' disease process monitoring. HMGB1 does not have a diagnostic value for sepsis patient identification.en
dc.description.statusPeer reviewed
dc.format.extent7
dc.format.extent97245
dc.identifier.citationPavare, J, Grope, I, Kalnins, I & Gardovska, D 2009, 'Diagnostic markers for early sepsis diagnosis in children with systemic inflammatory response syndrome', Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, vol. 63, no. 4-5, pp. 191-197. https://doi.org/10.2478/v10046-009-0048-z
dc.identifier.doi10.2478/v10046-009-0048-z
dc.identifier.issn1407-009X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/6945
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=73349098717&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChildren
dc.subjectDiagnostic markers
dc.subjectSepsis
dc.subjectSIRS
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral
dc.titleDiagnostic markers for early sepsis diagnosis in children with systemic inflammatory response syndromeen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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