Analysis of Morphological and Morphometric Changes in a Parenchymal Tissue after the Radiofrequency Ablation Procedure

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dc.contributor.authorSkaudickas, Darijus
dc.contributor.authorVaitiekaitis, Gintautas
dc.contributor.authorLiobikas, Julius
dc.contributor.authorGružienė, Aldona
dc.contributor.authorAbras, Marcel
dc.contributor.authorGersone, Gita
dc.contributor.authorVitkus, Aleksandras
dc.contributor.authorKerzienė, Sigita
dc.contributor.authorUndžytė, Greta
dc.contributor.authorVeikutis, Vincentas
dc.contributor.authorKašauskas, Artūras
dc.contributor.authorBaginskas, Armuntas
dc.contributor.authorNoreika, Algis
dc.contributor.institutionDepartment of Human Physiology and Biochemistry
dc.date.accessioned2023-08-14T09:50:02Z
dc.date.available2023-08-14T09:50:02Z
dc.date.issued2023-04
dc.descriptionPublisher Copyright: © 2023 by the authors.
dc.description.abstractBackground and Objectives: Prostate cancer is on the rise in the European Union, and radiofrequency ablation (RFA) is one of the minimally invasive treatment options used for its treatment. Therefore, the aim of this study was to investigate and analyze the effects of RFA on prostate tissues. Materials and Methods: A standard prostate RFA procedure was performed on 13 non-purebred dogs in three sessions: no cooling (NC), cooling with a 0.1% NaCl solution (C.01), and cooling using a 0.9% NaCl solution (C.09). Microtome-cut 2–3 µm sections of prostate samples were stained with hematoxylin and eosin and further examined. Results: A histopathologic evaluation identified four zones of exposure: direct, application, necrosis, and transitional, as the damage on tissues decreased going further from the ablation site. The areas and perimeters of these zones were calculated, and geometric shapes of ablative lesions were evaluated using the quotient formula. Areas and perimeters of prostate tissue lesions in the NC and C.09 sessions were of similar size, whereas those found in C.01 were statistically significantly smaller. Lesions observed in session C.01 were of the most regular geometric shape, while the most irregular ones were found in session C.09. The shapes of lesions closest to the ablation electrode were the most irregular, becoming more regular the further away from the electrode they were. Conclusions: Prostate RFA leads to tissue damage with distinct morphological zones. Notably, the prostate lesions were the smallest and the most regular in shape after RFA procedures using the 0.1% NaCl cooling solution. It can be argued that smaller ablation sites may result in smaller scars, thus allowing for faster tissue healing if the blood flow and innervation at the ablation site are not compromised.en
dc.description.statusPeer reviewed
dc.format.extent12
dc.format.extent2566748
dc.identifier.citationSkaudickas, D, Vaitiekaitis, G, Liobikas, J, Gružienė, A, Abras, M, Gersone, G, Vitkus, A, Kerzienė, S, Undžytė, G, Veikutis, V, Kašauskas, A, Baginskas, A & Noreika, A 2023, 'Analysis of Morphological and Morphometric Changes in a Parenchymal Tissue after the Radiofrequency Ablation Procedure', Medicina (Lithuania), vol. 59, no. 4, 702, pp. 1-12. https://doi.org/10.3390/medicina59040702
dc.identifier.doi10.3390/medicina59040702
dc.identifier.issn1010-660X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/14716
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85156173176&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofMedicina (Lithuania)
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectelectrode
dc.subjecthistology of prostate zones
dc.subjectmorphology
dc.subjectprostate
dc.subjectradiofrequency ablation
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral Medicine
dc.subjectSDG 3 - Good Health and Well-being
dc.titleAnalysis of Morphological and Morphometric Changes in a Parenchymal Tissue after the Radiofrequency Ablation Procedureen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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