Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues

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dc.contributor.authorMorris, Russell A.
dc.contributor.authorDamon, Brook
dc.contributor.authorMironov, Vladimir
dc.contributor.authorKasyanov, Vladimir
dc.contributor.authorRamamurthi, Anand
dc.contributor.authorMoreno-Rodriguez, Ricardo
dc.contributor.authorTrusk, Thomas
dc.contributor.authorPotts, Jay D.
dc.contributor.authorGoodwin, Richard L.
dc.contributor.authorDavis, Jeff
dc.contributor.authorHoffman, Stanley
dc.contributor.authorWen, Xuejun
dc.contributor.authorSugi, Yukiko
dc.contributor.authorKern, Christine B.
dc.contributor.authorMjaatvedt, Corey H.
dc.contributor.authorTurner, Debi K.
dc.contributor.authorOka, Toru
dc.contributor.authorConway, Simon J.
dc.contributor.authorMolkentin, Jeffery D.
dc.contributor.authorForgacs, Gabor
dc.contributor.authorMarkwald, Roger R.
dc.contributor.institutionRīga Stradiņš University
dc.date.accessioned2021-10-31T19:00:01Z
dc.date.available2021-10-31T19:00:01Z
dc.date.issued2007-06-01
dc.description.abstractPeriostin is predominantly expressed in collagen-rich fibrous connective tissues that are subjected to constant mechanical stresses including: heart valves, tendons, perichondrium, cornea, and the periodontal ligament (PDL). Based on these data we hypothesize that periostin can regulate collagen I fibrillogenesis and thereby affect the biomechanical properties of connective tissues. Immunoprecipitation and immunogold transmission electron microscopy experiments demonstrate that periostin is capable of directly interacting with collagen I. To analyze the potential role of periostin in collagen I fibrillogenesis, gene targeted mice were generated. Transmission electron microscopy and morphometric analyses demonstrated reduced collagen fibril diameters in skin dermis of periostin knockout mice, an indication of aberrant collagen I fibrillogenesis. In addition, differential scanning calorimetry (DSC) demonstrated a lower collagen denaturing temperature in periostin knockout mice, reflecting a reduced level of collagen cross-linking. Functional biomechanical properties of periostin null skin specimens and atrioventricular (AV) valve explant experiments provided direct evidence of the role that periostin plays in regulating the viscoelastic properties of connective tissues. Collectively, these data demonstrate for the first time that periostin can regulate collagen I fibrillogenesis and thereby serves as an important mediator of the biomechanical properties of fibrous connective tissues.en
dc.description.statusPeer reviewed
dc.format.extent17
dc.format.extent2522220
dc.identifier.citationMorris, R A, Damon, B, Mironov, V, Kasyanov, V, Ramamurthi, A, Moreno-Rodriguez, R, Trusk, T, Potts, J D, Goodwin, R L, Davis, J, Hoffman, S, Wen, X, Sugi, Y, Kern, C B, Mjaatvedt, C H, Turner, D K, Oka, T, Conway, S J, Molkentin, J D, Forgacs, G & Markwald, R R 2007, 'Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues', Journal of Cellular Biochemistry, vol. 101, no. 3, pp. 695-711. https://doi.org/10.1002/jcb.21224
dc.identifier.doi10.1002/jcb.21224
dc.identifier.issn0730-2312
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/6772
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=34247882685&partnerID=8YFLogxK
dc.identifier.urlhttp://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3393091&blobtype=pdf
dc.language.isoeng
dc.relation.ispartofJournal of Cellular Biochemistry
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCollagen
dc.subjectConnective tissues
dc.subjectFasciclin
dc.subjectFibrillogenesis
dc.subjectPeriostin
dc.subject1.6 Biological sciences
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectBiochemistry
dc.subjectMolecular Biology
dc.subjectCell Biology
dc.titlePeriostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissuesen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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