Squamous cell carcinoma "transformation" concurrent with secondary T790M mutation in resistant EGFR-mutated adenocarcinomas
No Thumbnail Available
Date
2016
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The authors report two cases of epidermal growth factor receptor gene (EGFR)-mutant stage IV lung adenocarcinomas developing immunohistochemically proven squamous cell carcinoma (SCC) "transformation" concurrently with T790M EGFR mutation, leading to acquired resistance to EGFR inhibitors. Moreover, the histologic change of EGFR-mutant lung adenocarcinoma into SCC has been recently reported in literature. The histological transformation to SCC appears as a novel mechanism of acquired EGFR TKI resistance in EGFR-mutated adenocarcinomas and it may be challenging for treatment.
Description
Publisher Copyright: © 2016 International Association for the Study of Lung Cancer. Published by Elsevier Inc.
Keywords
Adenocarcinoma, EGFR, Lung, Squamous cell carcinoma, T790M, 3.2 Clinical medicine, 1.1. Scientific article indexed in Web of Science and/or Scopus database, Oncology, Pulmonary and Respiratory Medicine
Citation
Jukna, A, Montanari, G, Mengoli, M C, Cavazza, A, Covi, M, Barbieri, F, Bertolini, F & Rossi, G 2016, 'Squamous cell carcinoma "transformation" concurrent with secondary T790M mutation in resistant EGFR-mutated adenocarcinomas', Journal of Thoracic Oncology, vol. 11, no. 4, pp. e49-e51. https://doi.org/10.1016/j.jtho.2015.12.096