Assessment of ADAMTS-13 Level in Hospitalized Children with Serious Bacterial Infections as a Possible Prognostic Marker

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dc.contributor.authorRautiainen, Linda
dc.contributor.authorCirko, Anna
dc.contributor.authorPavare, Jana
dc.contributor.authorBalmaks, Reinis
dc.contributor.authorGrope, Ilze
dc.contributor.authorKatirlo, Irina
dc.contributor.authorGersone, Gita
dc.contributor.authorTretjakovs, Peteris
dc.contributor.authorGardovska, Dace
dc.contributor.institutionDepartment of Paediatrics
dc.contributor.institutionDepartment of Human Physiology and Biochemistry
dc.date.accessioned2021-04-12T11:35:02Z
dc.date.available2021-04-12T11:35:02Z
dc.date.issued2019-08
dc.description.abstractBackground and objectives: In children, acute infection is the most common cause of visits in the primary care or emergency department. In 2002, criteria for diagnostics of pediatric sepsis were published, and then revised in 2016 as life-threatening organ dysfunction due to a dysregulated host response to infection. In the pathophysiology of sepsis endothelial dysfunction plays a very important role. Deficient proteolysis of von Willebrand factor, due to reduced ADAMTS-13 activity, results in disseminated platelet-rich thrombi in the microcirculation. ADAMTS-13 deficiency has been detected in systemic inflammation. The clinical relevance of ADAMTS-13 during sepsis is still unclear. We aimed to investigate the possible use of ADAMTS-13 as a prognostic marker in children with serious bacterial infection (SBI). Materials and Methods: Inclusion criteria were hospitalized children with SBI, aged from 1 month to 17 years. SBI was defined based on available clinical, imaging, and later also on microbiological data. Sepsis was diagnosed using criteria by The International Consensus Conference. In all the patients, the levels of ADAMTS-13 were measured at the time of inclusion. Results: Data from 71 patients were analyzed. A total of 47.9% (34) had sepsis, 21.1% (15) were admitted to the ICU, 8.5% (6) had mechanical ventilator support, and 4.2% (3) patients had a positive blood culture. The median level of ADAMTS-13 in this study population was 689.43 ng/mL. Patients with sepsis, patients admitted to the Intensive Care Unit, and patients in need of mechanical ventilator support had significantly lower levels of ADAMTS-13. None of the patients had ADAMTS-13 deficiency. In patients with SBI, the area under the curve (AUC) to predict sepsis was 0.67. A cut-off ADAMTS-13 level of <= 730.49 had 82% sensitivity and 60% specificity for sepsis in patients with SBI. Conclusions: ADATMS-13 levels were lower in patients with SBI and sepsis, but AUC and sensitivity were too low to accept it as a prognostic markeren
dc.description.statusPeer reviewed
dc.format.extent586058
dc.identifier.citationRautiainen, L, Cirko, A, Pavare, J, Balmaks, R, Grope, I, Katirlo, I, Gersone, G, Tretjakovs, P & Gardovska, D 2019, 'Assessment of ADAMTS-13 Level in Hospitalized Children with Serious Bacterial Infections as a Possible Prognostic Marker', Medicina (Kaunas), vol. 55, no. 8, 503. https://doi.org/10.3390/medicina55080503
dc.identifier.doi10.3390/medicina55080503
dc.identifier.issn1010-660X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/3754
dc.identifier.urlhttps://www.mdpi.com/1648-9144/55/8/503
dc.language.isoeng
dc.relation.ispartofMedicina (Kaunas)
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectserious bacterial infections
dc.subjectchildren
dc.subjectsepsis
dc.subjectADAMTS-13
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.titleAssessment of ADAMTS-13 Level in Hospitalized Children with Serious Bacterial Infections as a Possible Prognostic Markeren
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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