Association of Interleukin 6 Promoter Polymorphism (-174G/C) with IL-6 Level and Outcome in Severe Sepsis

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dc.contributor.authorSabelnikovs, Olegs
dc.contributor.authorNikitina-Zake, Liene
dc.contributor.authorVanags, Indulis
dc.contributor.institutionDepartment of Anaesthesiology, Intensive Care and Clinical simulations
dc.date.accessioned2021-10-20T10:30:01Z
dc.date.available2021-10-20T10:30:01Z
dc.date.issued2008-01
dc.description.abstractInterleukin (IL-6) is a key cytokine in the pathogenesis of severe sepsis. The importance of a regulatory polymorphism within the IL-6 promoter remains unclear in these patients. The aim of the study was to determine if IL-6 (-174 G/C) promoter polymorphism has an effect on IL-6plasma level and outcome of severe sepsis. The study was conducted in general ICU of Stradiņš Clinical University Hospital. A total of 103 critically ill patients with confirmed severe sepsis were prospectively included. Association analysis of the IL-6 (-174C) allele with serum level and clinical outcome was performed. We found no differences in genotype distribution between survivors and nonsurvivors. The serum IL-6 level was significantly higher in nonsurvivors compared with survivors. We found an association of genotype with the IL-6 level in non survivors, but not in survivors. Our findings show a functional significance of IL-6 promoter polymorphisms in nonsurviving severe sepsis patients.en
dc.description.statusPeer reviewed
dc.format.extent3
dc.format.extent58717
dc.identifier.citationSabelnikovs, O, Nikitina-Zake, L & Vanags, I 2008, 'Association of Interleukin 6 Promoter Polymorphism (-174G/C) with IL-6 Level and Outcome in Severe Sepsis', Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, vol. 62, no. 4/5, pp. 162-164. https://doi.org/10.2478/v10046-008-0019-9
dc.identifier.doi10.2478/v10046-008-0019-9
dc.identifier.issn1407-009X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/6676
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84994774832&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject174 C/G polymorphism
dc.subjectinterleukine-6
dc.subjectsevere sepsis
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral
dc.titleAssociation of Interleukin 6 Promoter Polymorphism (-174G/C) with IL-6 Level and Outcome in Severe Sepsisen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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