Oral mucosal changes caused by nicotine pouches : case series

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dc.contributor.authorMiļuna-Meldere, Sintija
dc.contributor.authorVanka, Šarlote Agate
dc.contributor.authorSkadiņš, Ingus
dc.contributor.authorKroiča, Juta
dc.contributor.authorSperga, Māris
dc.contributor.authorRostoka, Dagnija
dc.contributor.institutionDepartment of Prosthetic Dentistry
dc.contributor.institutionDepartment of Biology and Microbiology
dc.contributor.institutionDepartment of Pathology
dc.date.accessioned2024-09-23T10:20:02Z
dc.date.available2024-09-23T10:20:02Z
dc.date.issued2024-09-19
dc.descriptionPublisher Copyright: © The Author(s) 2024.
dc.description.abstractOral nicotine pouches are the latest products in the tobacco industry. They are manufactured by large tobacco companies and entice tobacco or nicotine addicts, although the products are presented as a ‘harmless choice.’ Nevertheless, dentists and oral health specialists worry about oral mucosal changes due to product interactions with the oral mucosa. Unfortunately, there are no case reports of oral mucosal changes from nicotine pouches that are also investigated histopathologically. The aim of the present study was to visually and histopathologically investigate oral mucosal changes in nicotine pouch users. An online retrospective survey regarding medical and dental health, dietary habits, and tobacco consumption habits was conducted (n = 50). Respondents were selected for further intraoral and histopathological investigation based on the inclusion criteria. All five respondents had oral lesions that were histopathologically analyzed. Visually, the lesions varied in form and intensity, but all appeared white at the location where the pouches were placed. Histopathological analyses revealed parakeratosis with acanthotic epithelium, intraepithelial and connective tissue oedema, and chronic inflammatory infiltration with lymphocytes and macrophages. Participants received information about nicotine cessation and oral health recommendations. In conclusion, nicotine pouches significantly impacted oral mucosa with white lesions that revealed important changes at the cellular level.en
dc.description.statusPeer reviewed
dc.format.extent10
dc.format.extent2042739
dc.identifier.citationMiļuna-Meldere, S, Vanka, Š A, Skadiņš, I, Kroiča, J, Sperga, M & Rostoka, D 2024, 'Oral mucosal changes caused by nicotine pouches : case series', Diagnostic Pathology, vol. 19, no. 1, 127, pp. 1-10. https://doi.org/10.1186/s13000-024-01549-3
dc.identifier.doi10.1186/s13000-024-01549-3
dc.identifier.issn1746-1596
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/16700
dc.identifier.urlhttps://www-webofscience-com.db.rsu.lv/wos/alldb/full-record/MEDLINE:39300504
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85204393249&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofDiagnostic Pathology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNicotine pouches
dc.subjectOral lesions
dc.subjectOral mucosa
dc.subjectParakeratosis
dc.subject1.6 Biological sciences
dc.subject3.2 Clinical medicine
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.titleOral mucosal changes caused by nicotine pouches : case seriesen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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