Pepsinogen testing for evaluation of the success of Helicobacter pylori eradication at 4 weeks after completion of therapy

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dc.contributor.authorLeja, Marcis
dc.contributor.authorLapina, Sanita
dc.contributor.authorPolaka, Inese
dc.contributor.authorRudzite, Dace
dc.contributor.authorVilkoite, Ilona
dc.contributor.authorDaugule, Ilva
dc.contributor.authorBelkovets, Anna
dc.contributor.authorPimanov, Sergey
dc.contributor.authorMakarenko, Jelena
dc.contributor.authorTolmanis, Ivars
dc.contributor.authorLejnieks, Aivars
dc.contributor.authorBoka, Viesturs
dc.contributor.authorRumba-Rozenfelde, Ingrida
dc.contributor.authorVikmanis, Uldis
dc.contributor.institutionRīga Stradiņš University
dc.date.accessioned2021-05-31T09:55:01Z
dc.date.available2021-05-31T09:55:01Z
dc.date.issued2014
dc.descriptionFunding Information: This study was supported in part from the European Fund for Regional Development project No. 2010/0302/2DP/2.1.1.1.0/10/APIA/VIAA/158 entitled “Development of a Genetic/Serological Biomarker Diagnostic Method for Early Identification of Autoimmune Gastrointestinal Lesions With Increased Malignancy Risk in Patients With Autoimmune Disease.” Publisher Copyright: © 2014 Lithuanian University of Health Sciences. Production and hosting by Elsevier Urban & Partner Sp. z o.o. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.
dc.description.abstractBackground and objective: Pepsinogen levels in plasma are increased by inflammation in the gastric mucosa, including inflammation resulting from Helicobacter pylori infection. A decrease in pepsinogen II level has been suggested as a reliable marker to confirm the successful eradication of infection. The aim of our study was to evaluate the potential role of pepsinogens I and II, gastrin-17 and H. pylori antibodies in confirming successful eradication. Material and methods: Altogether 42 patients (25 women, 17 men), mean age 45 years (range 23-74), were enrolled. Pepsinogens I and II, gastrin-17 and H. pylori IgG antibodies were measured in plasma samples using an ELISA test (Biohit, Oyj., Finland) before the eradication and 4 weeks after completing the treatment. The success of eradication was determined by a urea breath test. Results: Eradication was successful in 31 patients (74%) and unsuccessful in 11 patients (26%). Pepsinogen II decreased significantly in both the successful (P = 0.029) and unsuccessful (P = 0.042) eradication groups. Pepsinogen I decreased significantly in the successful (P = 0.025) but not the unsuccessful (P = 0.29) eradication group. The pepsinogen I/II ratio increased in the successful eradication group (P = 0.0018) but not in the group in which treatment failed (P = 0.12). There were no differences in gastrin-17 or H. pylori antibody values. Conclusions: A decrease in pepsinogen II levels cannot be used as a reliable marker for the successful eradication of H. pylori 4 weeks after the completion of treatment. The increase in pepsinogen I/II ratio reflects differences in pepsinogen production following the eradication irrespective of improvement in atrophy.en
dc.description.statusPeer reviewed
dc.format.extent6
dc.format.extent706109
dc.identifier.citationLeja, M, Lapina, S, Polaka, I, Rudzite, D, Vilkoite, I, Daugule, I, Belkovets, A, Pimanov, S, Makarenko, J, Tolmanis, I, Lejnieks, A, Boka, V, Rumba-Rozenfelde, I & Vikmanis, U 2014, 'Pepsinogen testing for evaluation of the success of Helicobacter pylori eradication at 4 weeks after completion of therapy', Medicina (Lithuania), vol. 50, no. 1, pp. 8-13. https://doi.org/10.1016/j.medici.2014.05.001
dc.identifier.doi10.1016/j.medici.2014.05.001
dc.identifier.issn1010-660X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/4581
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84906965400&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofMedicina (Lithuania)
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEfficacy
dc.subjectEradication
dc.subjectGastrin-17
dc.subjectHelicobacter pylori
dc.subjectPepsinogen
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral Medicine
dc.titlePepsinogen testing for evaluation of the success of Helicobacter pylori eradication at 4 weeks after completion of therapyen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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