Antiphospholipid antibodies and single nucleotide polymorphisms in patients with venous ulcer in the population of Latvia

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dc.contributor.authorKajuna, Irina
dc.contributor.authorStanevica, Valda
dc.contributor.authorMikažāne, Helēna
dc.contributor.institutionRīga Stradiņš University
dc.date.accessioned2022-11-21T12:50:02Z
dc.date.available2022-11-21T12:50:02Z
dc.date.issued2018
dc.description.abstractBackground: Chronic venous insufficiency (CVI) may lead to leg ulceration (CVI stage C6) (Nicolaides A.N. et al., 2000). Some authors published that genetic risk factors are observed more frequently in patients with CVI stage C6. Also, an increased level of anticardiolipin antibodies (ACA) is observed in patients with CVI stage C6. CVI stage C6 more frequently develops in CVI stage C3 patients with positive antiphospholipid antibodies (APA) when compared to CVI stage C3 patients without APA. Objective: To identify the association of single nucleotide polymorphisms (SNPs) of genes F5 (rs6025), F2 (rs1799963), SELE (rs5361), SERPINC1 (rs2227589), FGG (rs20066865), CYP4V2 (rs13146272), F11 (rs2289252), GP6 (rs1613662) and APA antibodies with CVI stage in the population of Latvia. Methods: The study group consisted of 188 CVI patients. APA was detected in 89 CVI patients. The diagnostics of CVI was based on clinical and duplex ultrasound data (Philips Sparq, 2012). APA was detected using ELISA assay (according to the manufacturer’s protocol (Demeditec Diagnostics GmbH, Germany)). Statistical analysis was performed using Plink 1.06. Software and Fisher exact tests. Results: Polymorphism of gene F11 (rs2289252) showed an association with CVI stage C6 (OR=1.81 (p=0.024). A statistically significant elevation of APA was observed in patients with CVI stage C6 when compared to patients with CVI stage C3 (p=0.05). Conclusions: The polymorphism of gene F11 (rs2289252) and positive APA showed an association with CVI stage C6.en
dc.description.statusPeer reviewed
dc.format.extent153477
dc.identifier.citationKajuna, I, Stanevica, V & Mikažāne, H 2018, 'Antiphospholipid antibodies and single nucleotide polymorphisms in patients with venous ulcer in the population of Latvia', International Journal of Clinical Rheumatology, vol. 13, no. 2, pp. 108-113. https://doi.org/10.4172/1758-4272.1000171
dc.identifier.doi10.4172/1758-4272.1000171
dc.identifier.issn1758-4272
dc.identifier.otherMendeley: 75c59712-5142-3751-9cf0-2ccef767ce1d
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/9793
dc.identifier.urlhttps://www.mendeley.com/catalogue/75c59712-5142-3751-9cf0-2ccef767ce1d/
dc.language.isoeng
dc.relation.ispartofInternational Journal of Clinical Rheumatology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectsingle nucleotide polymorphisms
dc.subjecttrophic ulcers
dc.subjectchronic venous insufficiency
dc.subjectvenous ulcer
dc.subjectantiphospholipid antibodies
dc.subjectanticardiolipin
dc.subjectantibodies
dc.subjectantiphospholipid
dc.subjectsyndrome
dc.subject3.2 Clinical medicine
dc.subject1.4. Reviewed scientific article published in Latvia or abroad in a scientific journal with an editorial board (including university editions)
dc.titleAntiphospholipid antibodies and single nucleotide polymorphisms in patients with venous ulcer in the population of Latviaen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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