Expression of p63, p53 and Ki-67 in patients with cervical intraepithelial neoplasia

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dc.contributor.authorMitildzans, Androniks
dc.contributor.authorArechvo, Anastasija
dc.contributor.authorRezeberga, Dace
dc.contributor.authorIsajevs, Sergejs
dc.contributor.institutionDepartment of Obstetrics and Gynaecology
dc.date.accessioned2021-06-14T09:20:01Z
dc.date.available2021-06-14T09:20:01Z
dc.date.issued2017
dc.descriptionPublisher Copyright: © 2016, Federation of Turkish Pathology Societies. All right reserved.
dc.description.abstractObjective: Cervical intraepithelial neoplasia (CIN) is a dysplastic process in cervical squamous epithelium and carries a risk of progression to cervical cancer. The aim of this study was to compare expression of three biomarkers named p53, p63 and Ki-67 in patients with various grades of cervical intraepithelial neoplasia and in a control group. Material and Method: 58 patients were enrolled in the study. Each patient underwent a colposcopy-guided biopsy of the cervix. Immunostaining for markers (p53, p63 and Ki-67) was performed on tissue samples of normal cases (n=10), CIN I (n=20), CIN II (n=14), and CIN III (n=14). Results: Our study showed a significant increase of the expression of the analyzed biomarkers in most patients with CIN III compared to CIN II and CIN I. Furthermore, p53 and p63 were significantly increased in CIN I compared to the control group. Conclusion: The expression of Ki-67, p63 and p53 differed between CIN I, CIN II and CIN III. p63 and p53 were reliable biomarkers to distinguish reactive changes from CIN I, while all three biomarkers (Ki-67, p53 and p63) had a high degree of sensitivity and specificity to distinguish between CIN III, CIN II and CIN I.en
dc.description.statusPeer reviewed
dc.format.extent8
dc.format.extent4071106
dc.identifier.citationMitildzans, A, Arechvo, A, Rezeberga, D & Isajevs, S 2017, 'Expression of p63, p53 and Ki-67 in patients with cervical intraepithelial neoplasia', Turk Patoloji Dergisi, vol. 33, no. 1, pp. 9-16. https://doi.org/10.5146/tjpath.2016.01373
dc.identifier.doi10.5146/tjpath.2016.01373
dc.identifier.issn1018-5615
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/4960
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85008319848&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofTurk Patoloji Dergisi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCervical intraepithelial neoplasia
dc.subjectKi-67
dc.subjectp53
dc.subjectp63
dc.subject3.1 Basic medicine
dc.subject3.5 Other medical sciences
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectPathology and Forensic Medicine
dc.subjectSDG 3 - Good Health and Well-being
dc.titleExpression of p63, p53 and Ki-67 in patients with cervical intraepithelial neoplasiaen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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