Efficacy and Safety of Quantum Molecular Resonance Electrotherapy in Patients with Aqueous-Deficient, Evaporative and Mixed-Type Dry Eye : A Randomized Interventional Study

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dc.contributor.authorBallesteros-Sánchez, Antonio
dc.contributor.authorSánchez-González, José María
dc.contributor.authorTedesco, Giovanni Roberto
dc.contributor.authorRocha-De-Lossada, Carlos
dc.contributor.authorRusso, Fedele
dc.contributor.authorSpinelli, Antonio
dc.contributor.authorIngrande, Irene
dc.contributor.authorBorroni, Davide
dc.contributor.institutionRīga Stradiņš University
dc.date.accessioned2024-02-26T11:30:01Z
dc.date.available2024-02-26T11:30:01Z
dc.date.issued2024-02
dc.descriptionPublisher Copyright: © 2023, The Author(s).
dc.description.abstractIntroduction: To evaluate the efficacy and safety of Quantum Molecular Resonance (QMR) treatment in patients with severe dry eye disease (DED), as well as its effects on aqueous-deficient (ADDE), evaporative (EDE), and mixed (MDE) dry eye. Methods: In this prospective, interventional study, 81 patients were randomly allocated to received four treatment sessions of QMR at 1-week intervals (Rexon-Eye®, Resono Ophthalmic, Trieste, Italy) (QRM group) or tear substitute four times daily, containing 0.15% sodium hyaluronate and 3% trehalose (Thealoz Duo®, Thea Pharma, France) (SH-TH group). Outcome measures included ocular surface disease index (OSDI) questionnaire, tear meniscus height (TMH), tear breakup time (TBUT), non-invasive breakup time (NIBUT), corneal fluorescein staining (CFS), lipid layer thickness (LLT), tear film osmolarity (OSM), and meibomian gland dysfunction (MGD) grade, which were assessed at baseline and 1-month and 3-month follow-up. Results: The QMR group achieved better improvements than the SH-TH group in OSDI and SANDE questionnaires, NIBUT, LLT, and CFS. The mean differences between the groups were as follows: OSDI (− 12.4 ± 0.25 points, P = 0.01), SANDE (10.6 ± 1.7 points, P = 0.01), NIBUT (2 ± 0.25 s, P = 0.01), LLT (18.7 ± 0.7 nm, P = 0.01), and CFS (1.2 ± 0.1 points, P = 0.02). In subgroups analysis, QMR treatment demonstrated a beneficial role to improve DED symptoms and signs in ADDE, EDE, and MDE. Conclusion: QMR is an effective and well-tolerated treatment that seems to improve DED symptoms and signs in patients with severe DED. However, further studies are needed to confirm this. Trial Registration: ClinicalTrials.gov identifier NCT06119386.en
dc.description.statusPeer reviewed
dc.format.extent13
dc.format.extent533751
dc.identifier.citationBallesteros-Sánchez, A, Sánchez-González, J M, Tedesco, G R, Rocha-De-Lossada, C, Russo, F, Spinelli, A, Ingrande, I & Borroni, D 2024, 'Efficacy and Safety of Quantum Molecular Resonance Electrotherapy in Patients with Aqueous-Deficient, Evaporative and Mixed-Type Dry Eye : A Randomized Interventional Study', Ophthalmology and Therapy, vol. 13, no. 2, pp. 495-507. https://doi.org/10.1007/s40123-023-00868-w
dc.identifier.doi10.1007/s40123-023-00868-w
dc.identifier.issn2193-8245
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/15333
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85180219271&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofOphthalmology and Therapy
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAqueous-deficient dry eye
dc.subjectDry eye disease
dc.subjectEvaporative dry eye
dc.subjectMeibomian gland dysfunction
dc.subjectMixed dry eye
dc.subjectQuantum Molecular Resonance electrotherapy
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectOphthalmology
dc.titleEfficacy and Safety of Quantum Molecular Resonance Electrotherapy in Patients with Aqueous-Deficient, Evaporative and Mixed-Type Dry Eye : A Randomized Interventional Studyen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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