Association of active human herpesvirus-6, -7 and parvovirus B19 infection with clinical outcomes in patients with myalgic encephalomyelitis/chronic fatigue syndrome

Simple item page
dc.contributor.authorChapenko, Svetlana
dc.contributor.authorKrumina, Angelika
dc.contributor.authorLogina, Inara
dc.contributor.authorRasa, Santa
dc.contributor.authorChistjakovs, Maksims
dc.contributor.authorSultanova, Alina
dc.contributor.authorViksna, Ludmila
dc.contributor.authorMurovska, Modra
dc.contributor.institutionDepartment of Infectology
dc.contributor.institutionDepartment of Neurology and Neurosurgery
dc.contributor.institutionInstitute of Microbiology and Virology
dc.date.accessioned2021-04-22T11:35:01Z
dc.date.available2021-04-22T11:35:01Z
dc.date.issued2012
dc.descriptionCopyright: Copyright 2013 Elsevier B.V., All rights reserved.
dc.description.abstractFrequency of active human herpesvirus-6, -7 (HHV-6, HHV-7) and parvovirus B19 (B19) infection/coinfection and its association with clinical course of ME/CFS was evaluated. 108 ME/CFS patients and 90 practically healthy persons were enrolled in the study. Viral genomic sequences were detected by PCR, virus-specific antibodies and cytokine levels - by ELISA, HHV-6 variants - by restriction analysis. Active viral infection including concurrent infection was found in 64.8% (70/108) of patients and in 13.3% (12/90) of practically healthy persons. Increase in peripheral blood leukocyte DNA HHV-6 load as well as in proinflammatory cytokines' levels was detected in patients during active viral infection. Definite relationship was observed between active betaherpesvirus infection and subfebrility, lymphadenopathy and malaise after exertion, and between active B19 infection and multijoint pain. Neuropsychological disturbances were detected in all patients. The manifestation of symptoms was of more frequent occurrence in patients with concurrent infection. The high rate of active HHV-6, HHV-7 and B19 infection/coinfection with the simultaneous increase in plasma proinflammatory cytokines' level as well as the association between active viral infection and distinctive types of clinical symptoms shows necessity of simultaneous study of these viral infections for identification of possible subsets of ME/CFS.en
dc.description.statusPeer reviewed
dc.identifier.citationChapenko , S , Krumina , A , Logina , I , Rasa , S , Chistjakovs , M , Sultanova , A , Viksna , L & Murovska , M 2012 , ' Association of active human herpesvirus-6, -7 and parvovirus B19 infection with clinical outcomes in patients with myalgic encephalomyelitis/chronic fatigue syndrome ' , Advances in Virology , vol. 2012 , 205085 . https://doi.org/10.1155/2012/205085
dc.identifier.doihttps://doi.org/10.1155/2012/205085
dc.identifier.issn1687-8639
dc.identifier.otherPURE: 23646971
dc.identifier.otherPURE UUID: 747a7955-4ce6-4cde-ad8e-8277623ec2bf
dc.identifier.otherScopus: 84873871748
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/3899
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84873871748&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofAdvances in Virology
dc.rights
dc.subjectVirology
dc.subjectInfectious Diseases
dc.subject1.6 Biological sciences
dc.subject3.3 Health sciences
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.titleAssociation of active human herpesvirus-6, -7 and parvovirus B19 infection with clinical outcomes in patients with myalgic encephalomyelitis/chronic fatigue syndromeen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

Files

Collections

Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure