The Role of the p16 and p53 Tumor Suppressor Proteins and Viral HPV16 E6 and E7 Oncoproteins in the Assessment of Survival in Patients with Head and Neck Cancers Associated with Human Papillomavirus Infections

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dc.contributor.authorLifsics, Andrejs
dc.contributor.authorCistjakovs, Maksims
dc.contributor.authorSokolovska, Liba
dc.contributor.authorDeksnis, Renars
dc.contributor.authorMurovska, Modra
dc.contributor.authorGroma, Valerija
dc.contributor.institutionDepartment of Otorhinolaryngology
dc.contributor.institutionInstitute of Microbiology and Virology
dc.contributor.institutionInstitute of Anatomy and Anthropology
dc.date.accessioned2023-05-16T07:30:02Z
dc.date.available2023-05-16T07:30:02Z
dc.date.issued2023-05-11
dc.descriptionFunding Information: This research was supported by the European Social Fund and the Latvian state budget within the frame of the project No. 8.2.2.0/20/l/004 “Support for involving doctoral students in scientific research and studies” at Riga Stradiņš University. The article processing charge was covered by Riga Stradinš University Department of Otorhinolaryngology. Publisher Copyright: © 2023 by the authors.
dc.description.abstractThe role of HPV in the survival prognosis of patients with head and neck squamous cell carcinoma, especially patients with laryngeal squamous cell carcinoma (LSCC) and hypopharyngeal squamous cell carcinoma (HPSCC), is still somewhat ambiguous. The present study aimed to explore the significance of tumor suppressor proteins and HPV16 E6 and E7 oncoproteins in the assessment of survival in patients with oropharyngeal squamous cell carcinoma (OPSCC), LSCC, and HPSCC associated with high-risk (HR-) and low-risk (LR-) HPV infections. By utilizing molecular and immunohistochemical investigations of HNSCC samples and patient data, univariate and multivariate survival analyses were conducted. The presence of HPV DNA (LR- and HR-HPV) was associated with a better 5-year OS and DSS for OPSCC and LSCC. The IHC overexpression of HPV16 E6 protein and p16 protein was associated with better survival in the univariate (for OPSCC) and multivariate (OPSCC and HPSCC) survival analyses. The overexpression of p53 was associated with better survival in OPSCC. HPV infection plays a significant role in the tumorigenesis of HNSCC, and the immunohistochemical assessment of HPV16 E6 protein expression should be interpreted as a useful prognostic marker for OPSCC and HPSCC.en
dc.description.statusPeer reviewed
dc.format.extent3829491
dc.identifier.citationLifsics, A, Cistjakovs, M, Sokolovska, L, Deksnis, R, Murovska, M & Groma, V 2023, 'The Role of the p16 and p53 Tumor Suppressor Proteins and Viral HPV16 E6 and E7 Oncoproteins in the Assessment of Survival in Patients with Head and Neck Cancers Associated with Human Papillomavirus Infections', Cancers, vol. 15, no. 10, 2722. https://doi.org/10.3390/cancers15102722
dc.identifier.doi10.3390/cancers15102722
dc.identifier.issn2072-6694
dc.identifier.otherunpaywall: 10.3390/cancers15102722
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/11979
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85160745733&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofCancers
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectOropharynx
dc.subjectlarynx
dc.subjecthypopharynx
dc.subjectsquamous cell carcinoma
dc.subjectHPV
dc.subjectPCR
dc.subjectimmunohistochemistry
dc.subjectp16
dc.subjectp53
dc.subjectE6/E7 viral oncoproteins
dc.subjectsurvival analysis
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectSDG 3 - Good Health and Well-being
dc.titleThe Role of the p16 and p53 Tumor Suppressor Proteins and Viral HPV16 E6 and E7 Oncoproteins in the Assessment of Survival in Patients with Head and Neck Cancers Associated with Human Papillomavirus Infectionsen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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