The Use of PRGF in Periodontal Regeneration Therapy
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Date
2021
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Rīgas Stradiņa universitāte
Rīga Stradiņš University
Rīga Stradiņš University
Abstract
Mērķis: Ar augšanas faktoriem bagātinātā plazma (PRGF) ir jauna un daudzsološa
tehnoloģija, ko var pielietot periodonta audu reģeneratīvajā ķiruģijā. Tomēr ir ļoti maz sistemātisku
pētījumu par PRGF pielietošanu dažādās klīniskās situācijās periodontoloģijā. Šis
aprakstošais pārskats ir mēģinājums veikt sistemātisku zinātnē balstītu rakstu meklēšanu un
apkopot uz šo brīdi pieejamo zinātnisko informāciju par PRGF klīnisko efektivitāti, to
pievienojot citiem materiāliem periodonta reģeneratīvajā terapijā.
Materiāli un metodes: Tika veikta sistemātiska rakstu meklēšana pēc atslēgas vārda
principa 5 dažādās datu bāzēs. Pēc pilna teksta skrīninga tika atlasīti 24 raksti, kas atbilda šī
pārskata iekļaušanas kritērijiem.
Rezultāti: Dažādas reģeneratīvās ārstēšanas pieejas tika novērtētas un grupētas pēc
indikācijām. Katrā no šīm grupām iegūtie dati tika apstrādāti un analizēti. Neviena no
grupām, tādas kā “smaganu recesija”, “intraalveolāri defekti”, “furkācijas iesaiste”, “zobu
ekstrakcija” un “pirmsprotezēšanas ķirurģija”, nevarēja uzrādīt ticamus, būtiski labākus
klīniskos rezultātus pēc PRGF pievienošanas, salīdzinot ar kontroles grupu. Tomēr PRGF
pozitīvi ietekmēja dzīšanas procesus un sāpju intensitāti pēc ķirurģiskās iejaukšanās.
Secinājums: Apskatītā literatūra atklāja divējādus PRGF pielietošanas rezultātus un
neatklāja nozīmīgus šīs metodes ieguvumus. Tomēr pašreizējais datu apjoms ir neliels, un
pētījumu apstākļi ļoti heterogēni. Ir nepieciešami turpmāki augsta līmeņa klīniski pētījumi
par PRGF.
Objective: Plasma rich in growth factors (PRGF) constitutes a new and promising technology that can be used in periodontal regenerative therapy. Nevertheless, systematic research about the application of PRGF in its full range of periodontal indications is rare if not missing. This narrative review attempts to systematically search and present the current scientific knowledge about the clinical effectiveness of PRGF in adjunction to periodontal regenerative therapy. Materials and Methods: A predefined search concept of key terms was systematically applied to five different databases. After full text screening, 24 articles have been identified and considered eligible for inclusion in this review. Results: Regenerative treatment approaches were assessed and grouped by indication. Among each of these groups, the provided data were processed and evaluated. None of the groups, such as “gingival recession”, “intrabony defects”, “furcation involvement”, “teeth extraction” and “preprosthetic surgery” could reveal clear significant better clinical outcomes after application of PRGF compared to a control group. Nonetheless, PRGF had positive effects on healing processes and pain management after intervention. Conclusion: The reviewed literature in its breadth revealed ambivalent outcomes and significant benefits of PRGF could not be stated. However, the current amount of data is small with heterogenous perspectives. Further high-level clinical research on PRGF is necessary.
Objective: Plasma rich in growth factors (PRGF) constitutes a new and promising technology that can be used in periodontal regenerative therapy. Nevertheless, systematic research about the application of PRGF in its full range of periodontal indications is rare if not missing. This narrative review attempts to systematically search and present the current scientific knowledge about the clinical effectiveness of PRGF in adjunction to periodontal regenerative therapy. Materials and Methods: A predefined search concept of key terms was systematically applied to five different databases. After full text screening, 24 articles have been identified and considered eligible for inclusion in this review. Results: Regenerative treatment approaches were assessed and grouped by indication. Among each of these groups, the provided data were processed and evaluated. None of the groups, such as “gingival recession”, “intrabony defects”, “furcation involvement”, “teeth extraction” and “preprosthetic surgery” could reveal clear significant better clinical outcomes after application of PRGF compared to a control group. Nonetheless, PRGF had positive effects on healing processes and pain management after intervention. Conclusion: The reviewed literature in its breadth revealed ambivalent outcomes and significant benefits of PRGF could not be stated. However, the current amount of data is small with heterogenous perspectives. Further high-level clinical research on PRGF is necessary.
Description
Zobārstniecība
Dentistry
Veselības aprūpe
Health Care
Dentistry
Veselības aprūpe
Health Care
Keywords
Ar augšanas faktoriem bagātinātā plazma; PRGF; Reģeneratīvā periodonta terapija; periodontīts, Plasma rich in growth factors; PRGF; Regenerative Periodontal Therapy, Periodontitis