The Molecular Interplay between Human Oncoviruses and Telomerase in Cancer Development

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dc.contributor.authorTornesello, Maria Lina
dc.contributor.authorCerasuolo, Andrea
dc.contributor.authorStarita, Noemy
dc.contributor.authorTornesello, Anna Lucia
dc.contributor.authorBonelli, Patrizia
dc.contributor.authorTuccillo, Franca Maria
dc.contributor.authorBuonaguro, Luigi
dc.contributor.authorIsaguliants, Maria G.
dc.contributor.authorBuonaguro, Franco M.
dc.contributor.institutionResearch Department
dc.date.accessioned2022-12-19T09:05:02Z
dc.date.available2022-12-19T09:05:02Z
dc.date.issued2022-10-26
dc.descriptionFunding Information: This work was supported by the Italian Ministry of Health Ricerca Corrente 2022 Grant L1/10. M.I. Isaguliants was supported by the Latvian Science Fund, project LZP 2021/1-0484. Publisher Copyright: © 2022 by the authors.
dc.description.abstractHuman oncoviruses are able to subvert telomerase function in cancer cells through multiple strategies. The activity of the catalytic subunit of telomerase (TERT) is universally enhanced in virus-related cancers. Viral oncoproteins, such as high-risk human papillomavirus (HPV) E6, Epstein–Barr virus (EBV) LMP1, Kaposi’s sarcoma-associated herpesvirus (HHV-8) LANA, hepatitis B virus (HBV) HBVx, hepatitis C virus (HCV) core protein and human T-cell leukemia virus-1 (HTLV-1) Tax protein, interact with regulatory elements in the infected cells and contribute to the transcriptional activation of TERT gene. Specifically, viral oncoproteins have been shown to bind TERT promoter, to induce post-transcriptional alterations of TERT mRNA and to cause epigenetic modifications, which have important effects on the regulation of telomeric and extra-telomeric functions of the telomerase. Other viruses, such as herpesviruses, operate by integrating their genomes within the telomeres or by inducing alternative lengthening of telomeres (ALT) in non-ALT cells. In this review, we recapitulate on recent findings on virus–telomerase/telomeres interplay and the importance of TERT-related oncogenic pathways activated by cancer-causing viruses.en
dc.description.statusPeer reviewed
dc.format.extent961133
dc.identifier.citationTornesello, M L, Cerasuolo, A, Starita, N, Tornesello, A L, Bonelli, P, Tuccillo, F M, Buonaguro, L, Isaguliants, M G & Buonaguro, F M 2022, 'The Molecular Interplay between Human Oncoviruses and Telomerase in Cancer Development', Cancers, vol. 14, no. 21, 5257. https://doi.org/10.3390/cancers14215257
dc.identifier.doi10.3390/cancers14215257
dc.identifier.issn2072-6694
dc.identifier.otherunpaywall: 10.3390/cancers14215257
dc.identifier.otherMendeley: 1c647a42-4b1d-3cd0-8c43-baa9134139ea
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/9863
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85141818729&partnerID=8YFLogxK
dc.identifier.urlhttps://www.mendeley.com/catalogue/1c647a42-4b1d-3cd0-8c43-baa9134139ea/
dc.language.isoeng
dc.relation.ispartofCancers
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEBV
dc.subjectEpstein–Barr virus
dc.subjectHBV
dc.subjectHCV
dc.subjecthepatitis B virus
dc.subjecthepatitis C virus
dc.subjectHHV-8
dc.subjectHPV
dc.subjectHTLV-1
dc.subjecthuman papillomavirus
dc.subjecthuman T-cell leukemia virus-1
dc.subjectKaposi’s sarcoma-associated herpesvirus
dc.subjecttelomerase reverse transcriptase
dc.subjectTERT
dc.subjectTERT promoter
dc.subjectTERTp
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectOncology
dc.subjectCancer Research
dc.subjectSDG 3 - Good Health and Well-being
dc.titleThe Molecular Interplay between Human Oncoviruses and Telomerase in Cancer Developmenten
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/systematicreview

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