Tumour Microenvironment : The General Principles of Pathogenesis and Implications in Diffuse Large B Cell Lymphoma

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dc.contributor.authorSinkarevs, Stanislavs
dc.contributor.authorStrumfs, Boriss
dc.contributor.authorVolkova, Svetlana
dc.contributor.authorStrumfa, Ilze
dc.contributor.institutionDepartment of Pathology
dc.date.accessioned2024-08-05T10:20:01Z
dc.date.available2024-08-05T10:20:01Z
dc.date.issued2024-06
dc.descriptionPublisher Copyright: © 2024 by the authors.
dc.description.abstractDiffuse large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma worldwide, constituting around 30–40% of all cases. Almost 60% of patients develop relapse of refractory DLBCL. Among the reasons for the therapy failure, tumour microenvironment (TME) components could be involved, including tumour-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), tumour-associated neutrophils (TANs), cancer-associated fibroblasts (CAFs), and different subtypes of cytotoxic CD8+ cells and T regulatory cells, which show complex interactions with tumour cells. Understanding of the TME can provide new therapeutic options for patients with DLBCL and improve their prognosis and overall survival. This review provides essentials of the latest understanding of tumour microenvironment elements and discusses their role in tumour progression and immune suppression mechanisms which result in poor prognosis for patients with DLBCL. In addition, we point out important markers for the diagnostic purposes and highlight novel therapeutic targets.en
dc.description.statusPeer reviewed
dc.format.extent19
dc.format.extent2521197
dc.identifier.citationSinkarevs, S, Strumfs, B, Volkova, S & Strumfa, I 2024, 'Tumour Microenvironment : The General Principles of Pathogenesis and Implications in Diffuse Large B Cell Lymphoma', Cells, vol. 13, no. 12, 1057, pp. 1-19. https://doi.org/10.3390/cells13121057, https://doi.org/10.3390/cells13121057
dc.identifier.doi10.3390/cells13121057
dc.identifier.issn2073-4409
dc.identifier.otherMendeley: 58aac4ad-d56b-3a92-85c3-7d45628c1d7a
dc.identifier.otherunpaywall: 10.3390/cells13121057
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/16480
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85197053293&partnerID=8YFLogxK
dc.identifier.urlhttps://www.mendeley.com/catalogue/58aac4ad-d56b-3a92-85c3-7d45628c1d7a/
dc.language.isoeng
dc.relation.ispartofCells
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcancer-associated fibroblasts (CAF)
dc.subjectdiffuse large B cell lymphoma (DLBCL)
dc.subjectT cell
dc.subjecttumour microenvironment (TME)
dc.subjecttumour-associated macrophages (TAM)
dc.subjecttumour-associated neutrophils (TAN)
dc.subjectMyeloid-Derived Suppressor Cells/pathology
dc.subjectLymphoma, Large B-Cell, Diffuse/pathology
dc.subjectAnimals
dc.subjectTumor Microenvironment/immunology
dc.subjectHumans
dc.subject3.1 Basic medicine
dc.subject1.6 Biological sciences
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral Biochemistry,Genetics and Molecular Biology
dc.subjectSDG 3 - Good Health and Well-being
dc.titleTumour Microenvironment : The General Principles of Pathogenesis and Implications in Diffuse Large B Cell Lymphomaen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/systematicreview

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