Organic Solvents Impact on Industrial Workers Central and Peripheral Nervous System
No Thumbnail Available
Date
2022
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Rīgas Stradiņa universitāte
Rīga Stradiņš University
Rīga Stradiņš University
Abstract
Pamatojums: Hroniska organisko šķīdinātāju iedarbība un tās ietekme uz veselību joprojām ir būtisks jautājums. Iepriekšējā gadsimta otrajā pusē veikto pētījumu rezultātā visā pasaulē tika pieņemta virkne tiesisko regulējumu, taču ievērojama globālā darbaspēka daļa joprojām ir apdraudēta, un produkti ar augstu šķīdinātāju saturu ir plaši pieejami un populāri.
Mērķis: Novērtēt pašreizējos statistiski ticamos pierādījumus par šķīdinātāju neirotoksicitāti, tostarp kohortas no iepriekšējā un pašreizējā gadsimtiem.
Metodes: Literatūras apskats tika veikts, izmantojot PubMed, Google Scholar un Science Direct datu bāzes. Tajā tika iekļauti pētījumi, kas publicēti no 2011. līdz 2022. gadam. Tika izmantoti šādi meklēšanas vienumi, izmantojot Būla operatorus “UN” un “OR”: organiskie šķīdinātāji, gaistošie organiskie savienojumi, GOS, toluols, stirols, BTEX, darbinieki, iedarbība darbā, neirotoksicitāte, nervu sistēma, encefalopātija, neirodeģeneratīvās slimības, Parkinsona slimība, Alcheimera slimība.
Secinājums: Apskatītā literatūra sniedz pierādījumus par saistību starp šķīdinātāju iedarbību un neirotoksicitātes simptomiem. Riski var saglabāties, ja iedarbības līmenis ir zemāks par darba standartiem, neskatoties uz mūsdienu darbinieku aizsardzību. Organisko šķīdinātāju loma neirodeģeneratīvo slimību attīstībā joprojām nav skaidra. Trihloretilēna iedarbība ir saistīta ar Parkinsona slimību, taču nav drošu pierādījumu, ka šķīdinātāju iedarbība kopumā radītu šādu risku. Pastāvīgi ir nepieciešama darbinieku aizsardzība, tādēļ tiek ieviestas izmaiņas šķīdinātāju ķīmiskajā sastāvā un darba vietās tiek izmantotas jaunas vielas, lai aizstātu šķīdinātājus ar pierādītām neirotoksiskām īpašībām.
Objectives: Chronic occupational solvent exposure and its health impact remains an issue of substantial interest. The research that was performed during the second half of the previous century resulted in a range of legal regulations across the world, but a significant portion of the global workforce remains at-risk, and products with high solvent content remain highly available and popular. Aim: To evaluate current statistical evidence for solvent neurotoxicity including cohorts from the previous and current century. Methods: A literature review was conducted using the PubMed, Google Scholar, and Science Direct databases. It included studies published from 2011 to 2022. The following search terms were utilized, applying Boolean operators “AND” and “OR”: Organic solvents, volatile organic compounds, VOC, toluene, styrene, BTEX, workers, occupational exposure, neurotoxicity, nervous system, encephalopathy, neurodegenerative diseases, Parkinson’s disease, Alzheimer’s disease. Conclusion: The reviewed literature provides evidence for a positive association between solvent exposure and symptoms of neurotoxicity. Risks may persist at exposure levels below occupational standards, and despite contemporary worker protection. The role of organic solvents in the development of neurodegenerative diseases remains unclear. Exposure to trichloroethylene is positively associated with Parkinson’s disease, but there is no evidence that solvent exposure in general poses such risk. There is a persistent need for worker protection as changes in chemical composition are implemented and new substances are introduced into the workplace to replace solvents with proven neurotoxic properties.
Objectives: Chronic occupational solvent exposure and its health impact remains an issue of substantial interest. The research that was performed during the second half of the previous century resulted in a range of legal regulations across the world, but a significant portion of the global workforce remains at-risk, and products with high solvent content remain highly available and popular. Aim: To evaluate current statistical evidence for solvent neurotoxicity including cohorts from the previous and current century. Methods: A literature review was conducted using the PubMed, Google Scholar, and Science Direct databases. It included studies published from 2011 to 2022. The following search terms were utilized, applying Boolean operators “AND” and “OR”: Organic solvents, volatile organic compounds, VOC, toluene, styrene, BTEX, workers, occupational exposure, neurotoxicity, nervous system, encephalopathy, neurodegenerative diseases, Parkinson’s disease, Alzheimer’s disease. Conclusion: The reviewed literature provides evidence for a positive association between solvent exposure and symptoms of neurotoxicity. Risks may persist at exposure levels below occupational standards, and despite contemporary worker protection. The role of organic solvents in the development of neurodegenerative diseases remains unclear. Exposure to trichloroethylene is positively associated with Parkinson’s disease, but there is no evidence that solvent exposure in general poses such risk. There is a persistent need for worker protection as changes in chemical composition are implemented and new substances are introduced into the workplace to replace solvents with proven neurotoxic properties.
Description
Medicīna
Medicine
Veselības aprūpe
Health Care
Medicine
Veselības aprūpe
Health Care
Keywords
Organiskie šķīdinātāji, gaistošie organiskie savienojumi, GOS, toluols, stirols, BTEX, darbinieki, iedarbība darbā, neirotoksicitāte, encefalopātija, neirodeģeneratīvās slimības, Parkinsona slimība, Alcheimera slimība., Organic solvents, volatile organic compounds, VOC, toluene, styrene, BTEX, workers, occupational exposure, neurotoxicity, encephalopathy, neurodegenerative diseases, Parkinson disease, Alzheimer disease.