The Transcriptome and Proteome Networks of Malignant Tumours Reveal Atavistic Attractors of Polyploidy-Related Asexual Reproduction

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dc.contributor.authorVainshelbaum, Ninel M.
dc.contributor.authorGiuliani, Alessandro
dc.contributor.authorSalmina, Kristine
dc.contributor.authorPjanova, Dace
dc.contributor.authorĒrenpreisa, Jekaterina
dc.date.accessioned2023-08-07T09:15:01Z
dc.date.available2023-08-07T09:15:01Z
dc.date.issued2022-12
dc.descriptionFunding Information: This research was supported by the University of Latvia Doctoral Student Scholarship in the Life, Exact, and Medical Sciences and the 8.2.2.0/20/I/006 “University of Latvia Doctoral Study Program Capacity Enhancement Through a New PhD Model” project for N.M.V., by a grant from the European Regional Development Fund (ERDF) project No. 1.1.1.2/VIAA/3/19/463 for KS. Publisher Copyright: © 2022 by the authors.
dc.description.abstractThe expression of gametogenesis-related (GG) genes and proteins, as well as whole genome duplications (WGD), are the hallmarks of cancer related to poor prognosis. Currently, it is not clear if these hallmarks are random processes associated only with genome instability or are programmatically linked. Our goal was to elucidate this via a thorough bioinformatics analysis of 1474 GG genes in the context of WGD. We examined their association in protein–protein interaction and coexpression networks, and their phylostratigraphic profiles from publicly available patient tumour data. The results show that GG genes are upregulated in most WGD-enriched somatic cancers at the transcriptome level and reveal robust GG gene expression at the protein level, as well as the ability to associate into correlation networks and enrich the reproductive modules. GG gene phylostratigraphy displayed in WGD+ cancers an attractor of early eukaryotic origin for DNA recombination and meiosis, and one relative to oocyte maturation and embryogenesis from early multicellular organisms. The upregulation of cancer–testis genes emerging with mammalian placentation was also associated with WGD. In general, the results suggest the role of polyploidy for soma–germ transition accessing latent cancer attractors in the human genome network, which appear as pre-formed along the whole Evolution of Life.en
dc.description.statusPeer reviewed
dc.format.extent8056562
dc.identifier.citationVainshelbaum, N M, Giuliani, A, Salmina, K, Pjanova, D & Ērenpreisa, J 2022, 'The Transcriptome and Proteome Networks of Malignant Tumours Reveal Atavistic Attractors of Polyploidy-Related Asexual Reproduction', International Journal of Molecular Sciences, vol. 23, no. 23, 14930. https://doi.org/10.3390/ijms232314930
dc.identifier.doi10.3390/ijms232314930
dc.identifier.issn1661-6596
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/14277
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85143745326&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectatavism
dc.subjectbasic meiosis attractor
dc.subjectbiological interaction networks
dc.subjectcancer
dc.subjectearly embryo
dc.subjectfemale meiosis
dc.subjectgene phylostratigraphy
dc.subjectpseudo-placentation
dc.subjectsoma–germ transition
dc.subjectwhole genome duplications
dc.subject1.6 Biological sciences
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectCatalysis
dc.subjectMolecular Biology
dc.subjectSpectroscopy
dc.subjectComputer Science Applications
dc.subjectPhysical and Theoretical Chemistry
dc.subjectOrganic Chemistry
dc.subjectInorganic Chemistry
dc.subjectSDG 3 - Good Health and Well-being
dc.titleThe Transcriptome and Proteome Networks of Malignant Tumours Reveal Atavistic Attractors of Polyploidy-Related Asexual Reproductionen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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