Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis

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dc.contributor.authorIvanov, Alexander V.
dc.contributor.authorValuev-Elliston, Vladimir T.
dc.contributor.authorTyurina, Daria A.
dc.contributor.authorIvanova, Olga N.
dc.contributor.authorKochetkov, Sergey N.
dc.contributor.authorBartosch, Birke
dc.contributor.authorIsaguliants, Maria G.
dc.contributor.institutionRīga Stradiņš University
dc.date.accessioned2021-06-15T10:05:01Z
dc.date.available2021-06-15T10:05:01Z
dc.date.issued2017
dc.description.abstractVirally induced liver cancer usually evolves over long periods of time in the context of a strongly oxidative microenvironment, characterized by chronic liver inflammation and regeneration processes. They ultimately lead to oncogenic mutations in many cellular signaling cascades that drive cell growth and proliferation. Oxidative stress, induced by hepatitis viruses, therefore is one of the factors that drives the neoplastic transformation process in the liver. This review summarizes current knowledge on oxidative stress and oxidative stress responses induced by human hepatitis B and C viruses. It focuses on the molecular mechanisms by which these viruses activate cellular enzymes/systems that generate or scavenge reactive oxygen species (ROS) and control cellular redox homeostasis. The impact of an altered cellular redox homeostasis on the initiation and establishment of chronic viral infection, as well as on the course and outcome of liver fibrosis and hepatocarcinogenesis will be discussed The review neither discusses reactive nitrogen species, although their metabolism is interferes with that of ROS, nor antioxidants as potential therapeutic remedies against viral infections, both subjects meriting an independent review.en
dc.description.statusPeer reviewed
dc.format.extent38
dc.format.extent3674179
dc.identifier.citationIvanov, A V, Valuev-Elliston, V T, Tyurina, D A, Ivanova, O N, Kochetkov, S N, Bartosch, B & Isaguliants, M G 2017, 'Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis', Oncotarget, vol. 8, no. 3, pp. 3895-3932. https://doi.org/10.18632/oncotarget.13904
dc.identifier.doi10.18632/oncotarget.13904
dc.identifier.issn1949-2553
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/5035
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85011990315&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofOncotarget
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCarcinogenesis
dc.subjectHepatitis B virus
dc.subjectHepatitis C virus
dc.subjectPathogenesis
dc.subjectReactive oxygen species
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectOncology
dc.subjectSDG 3 - Good Health and Well-being
dc.titleOxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesisen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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