Assessment of Cardiac Resynchronisation Therapy Efficacy Determining Factors for Patients with Moderate and Severe Heart Failure in the Population of Latvia in a 12 and 24 Month Study

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dc.contributor.authorVikmane, Maija
dc.contributor.authorKalejs, Oskars
dc.contributor.authorKamzola, Ginta
dc.contributor.authorUpite, Dana
dc.contributor.authorVentiņa, Madara
dc.contributor.authorNesterovičs, Nikolajs
dc.contributor.authorLejnieks, Aivars
dc.contributor.institutionDepartment of Internal Diseases
dc.date.accessioned2021-06-21T09:15:01Z
dc.date.available2021-06-21T09:15:01Z
dc.date.issued2018-12-01
dc.descriptionPublisher Copyright: © 2018 Maija Vikmane et al.
dc.description.abstractThe aim of this study was to evaluate treatment of patients with moderate and severe heart failure (HF) who were resistant to pharmacotherapy in Latvia and to assess the cardiac resynchronisation therapy (CRT) by exploring the predisposing factors which provides CRT efficacy. We accomplished prospective analysis of left ventricle ejection fraction (LVEF) and other parameter changes 12 and 24 months after CRT device implantation, dividing the population into two groups: responders - to whom LVEF improvement was ≥10% and non-responders where ≥ 10% LVEF improvement was not achieved. The study included 50 chronic HF patients with preserved sinus rhythm, who underwent CRT device implantation in Latvia at the Pauls Stradiņš Clinical University Hospital from June 2009 to March 2012. In the group of patients where 12 and 24 months after CRT device implantation LVEF improvement ≥10% was achieved, there were statistically significantly more patients with left bundle branch block (LBBB) QRS morphology, wider QRS complex, nonischemic genesis of HF, and normal systolic blood pressure. Patients with LVEF improvement had more pronounced ventricular dyssynchrony measured by Echo before CRT device implantation and, accordingly, the CRT mode was programmed as left ventricle paced before right ventricle and close to 100% biventricular pacing was achieved and the patient was female.en
dc.description.statusPeer reviewed
dc.format.extent9
dc.format.extent380111
dc.identifier.citationVikmane, M, Kalejs, O, Kamzola, G, Upite, D, Ventiņa, M, Nesterovičs, N & Lejnieks, A 2018, 'Assessment of Cardiac Resynchronisation Therapy Efficacy Determining Factors for Patients with Moderate and Severe Heart Failure in the Population of Latvia in a 12 and 24 Month Study', Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, vol. 72, no. 6, pp. 313-321. https://doi.org/10.2478/prolas-2018-0049
dc.identifier.doi10.2478/prolas-2018-0049
dc.identifier.issn1407-009X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/5339
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85059560694&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcardiac resynchronisation therapy
dc.subjectheart failure
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral
dc.titleAssessment of Cardiac Resynchronisation Therapy Efficacy Determining Factors for Patients with Moderate and Severe Heart Failure in the Population of Latvia in a 12 and 24 Month Studyen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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