Chronic viral infections in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
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Date
2018-10-01
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Abstract
Background and main text: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex and controversial clinical condition without having established causative factors. Increasing numbers of cases during past decade have created awareness among patients as well as healthcare professionals. Chronic viral infection as a cause of ME/CFS has long been debated. However, lack of large studies involving well-designed patient groups and validated experimental set ups have hindered our knowledge about this disease. Moreover, recent developments regarding molecular mechanism of pathogenesis of various infectious agents cast doubts over validity of several of the past studies. Conclusions: This review aims to compile all the studies done so far to investigate various viral agents that could be associated with ME/CFS. Furthermore, we suggest strategies to better design future studies on the role of viral infections in ME/CFS.
Description
Funding Information: This review is based upon work from European Network on Myalgic Encepha‑ lomyelitis/Chronic Fatigue Syndrome (EUROMENE) as part of COST Action CA15111 supported by the EU Framework Program Horizon 2020 (Website: http://www.cost.eu/COST_Actions/ca/CA15111). Other funding sources—the Bulgarian National Science Fund [ДКOCT 01/9 to E.S.], Solve ME/CFS Initiative, USA (to BKP). Publisher Copyright: © 2018 The Author(s). Copyright: Copyright 2018 Elsevier B.V., All rights reserved.
Keywords
Biomarkers, ME/CFS, Viral infections, 1.1. Scientific article indexed in Web of Science and/or Scopus database, General Biochemistry,Genetics and Molecular Biology
Citation
Rasa, S, Nora-Krukle, Z, Henning, N, Eliassen, E, Shikova, E, Harrer, T, Scheibenbogen, C, Murovska, M & Prusty, B K 2018, 'Chronic viral infections in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)', Journal of Translational Medicine, vol. 16, no. 1, 268, pp. 268. https://doi.org/10.1186/s12967-018-1644-y, https://doi.org/10.1186/s12967-018-1644-y