Short- and mid-term outcomes of multisystem inflammatory syndrome in children : a longitudinal prospective single-center cohort study

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dc.contributor.authorRoge, Ieva
dc.contributor.authorKivite-Urtane, Anda
dc.contributor.authorSmane, Liene
dc.contributor.authorMeiere, Anija
dc.contributor.authorKlavina, Lizete
dc.contributor.authorBarzdina, Elza
dc.contributor.authorPavare, Jana
dc.contributor.institutionDepartment of Paediatrics
dc.contributor.institutionDepartment of Public Health and Epidemiology
dc.date.accessioned2023-10-17T09:20:01Z
dc.date.available2023-10-17T09:20:01Z
dc.date.issued2023
dc.descriptionFunding Information: We sincerely thank the patients and their families for participating in and cooperation with this study. We would also like to thank the team of cardiologists at CCUH, particularly Inguna Lubaua and Emils Smitins, for their excellent cooperation in patient care and dynamic monitoring throughout this study. Publisher Copyright: 2023 Roge, Kivite-Urtane, Smane, Meiere, Klavina, Barzdina and Pavare.
dc.description.abstractBackground: Multisystem inflammatory syndrome in children (MIS-c) emerged during the coronavirus disease 2019 pandemic and is associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite the extensively studied clinical manifestation of acute condition, the short- and long-term effects of MIS-c on children's health are unknown. Methods: This was a prospective longitudinal cohort study. Children aged <18 years who met the Centers for Disease Prevention and Control (CDC) diagnostic criteria and who were admitted to the Children's Clinical University Hospital of Latvia (CCUH) between July 1, 2020, and April 15, 2022, were enrolled in the study. An outpatient follow-up program was initiated in July 2020. All children were evaluated at 2 weeks, 2 months (1–3 months), and 6 months (5–7 months) after discharge. The face-to-face interviews comprised four domains as follows: symptom assessment, physical examination, laboratory testing, and cardiological investigation [including electrocardiogram (ECG) and echocardiography (echo)]. Results: Overall, 21 patients with MIS-c were enrolled. The median age of the study group was 6 years. At the 2-week follow-up, almost half of the patients (N = 10, 47.6%) reported exercise intolerance with provoked tiredness. Laboratory tests showed a considerable increase in blood cell count, with a near doubling of leukocyte and neutrophil counts and a tripling of thrombocyte levels. However, a decline in the levels of inflammatory and organ-specific markers was observed. Cardiological investigation showed significant improvement with gradual resolution of the acute-phase pathological findings. Within 2 months, improvement in exercise capacity was observed with 5-fold and 2-fold reductions in physical intolerance (N = 2, 9.5%) and physical activity-induced fatigue (N = 5, 23.8%), respectively. Normalization of all blood cell lines was observed, and cardiological investigation showed no persistent changes. At the 6-month visit, further improvement in the children's exercise capacity was observed, and both laboratory and cardiological investigation showed no pathological changes. Conclusions: Most persistent symptoms were reported within the first 2 weeks after the acute phase, with decreased physical activity tolerance and activity-induced fatigue as the main features. A positive trend was observed at each follow-up visit as the spectrum of the children's complaints decreased. Furthermore, rapid normalization of laboratory markers and cardiac abnormalities was observed.en
dc.description.statusPeer reviewed
dc.format.extent296995
dc.identifier.citationRoge, I, Kivite-Urtane, A, Smane, L, Meiere, A, Klavina, L, Barzdina, E & Pavare, J 2023, 'Short- and mid-term outcomes of multisystem inflammatory syndrome in children : a longitudinal prospective single-center cohort study', Frontiers in Pediatrics, vol. 11, 1223266. https://doi.org/10.3389/fped.2023.1223266
dc.identifier.doi10.3389/fped.2023.1223266
dc.identifier.issn2296-2360
dc.identifier.otherMendeley: 11be975d-43f7-320d-84dd-5a02f4d868e9
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/14915
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85169335264&partnerID=8YFLogxK
dc.identifier.urlhttps://www.mendeley.com/catalogue/11be975d-43f7-320d-84dd-5a02f4d868e9/
dc.language.isoeng
dc.relation.ispartofFrontiers in Pediatrics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcoronavirus disease 2019
dc.subjectmulti-organ damage
dc.subjectmultisystem inflammatory syndrome in children
dc.subjectpediatric
dc.subjectsevere acute respiratory syndrome coronavirus 2
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectPediatrics, Perinatology, and Child Health
dc.titleShort- and mid-term outcomes of multisystem inflammatory syndrome in children : a longitudinal prospective single-center cohort studyen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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