Failure or future? Exploring alternative antibacterials : a comparative analysis of antibiotics and naturally derived biopolymers

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dc.contributor.authorSceglovs, Artemijs
dc.contributor.authorSkadiņš, Ingus
dc.contributor.authorChitto, Marco
dc.contributor.authorKroiča, Juta
dc.contributor.authorSalma-Ancane, Kristīne
dc.contributor.institutionDepartment of Biology and Microbiology
dc.date.accessioned2025-02-05T09:15:01Z
dc.date.available2025-02-05T09:15:01Z
dc.date.issued2025-02-03
dc.descriptionPublisher Copyright: Copyright © 2025 Sceglovs, Skadins, Chitto, Kroica and Salma-Ancane.
dc.description.abstractThe global crisis of antimicrobial resistance (AMR) is escalating due to the misuse and overuse of antibiotics, the slow development of new therapies, and the rise of multidrug-resistant (MDR) infections. Traditional antibiotic treatments face limitations, including the development of resistance, disruption of the microbiota, adverse side effects, and environmental impact, emphasizing the urgent need for innovative alternative antibacterial strategies. This review critically examines naturally derived biopolymers with intrinsic (essential feature) antibacterial properties as a sustainable, next-generation alternative to traditional antibiotics. These biopolymers may address bacterial resistance uniquely by disrupting bacterial membranes rather than cellular functions, potentially reducing microbiota interference. Through a comparative analysis of the mechanisms and applications of antibiotics and antibacterial naturally derived biopolymers, this review highlights the potential of such biopolymers to address AMR while supporting human and environmental health.en
dc.description.statusPeer reviewed
dc.format.extent17
dc.format.extent8479560
dc.identifier.citationSceglovs, A, Skadiņš, I, Chitto, M, Kroiča, J & Salma-Ancane, K 2025, 'Failure or future? Exploring alternative antibacterials : a comparative analysis of antibiotics and naturally derived biopolymers', Frontiers in Microbiology, vol. 16 , 1526250, pp. 1526250. https://doi.org/10.3389/fmicb.2025.1526250
dc.identifier.doi10.3389/fmicb.2025.1526250
dc.identifier.issn1664-302X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/17072
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85218185850&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofFrontiers in Microbiology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectantibacterial naturally derived biopolymers
dc.subjectantibiotic
dc.subjectAntibiotic resistance
dc.subjectbacterial infection
dc.subjectmechanism of action
dc.subject3.1 Basic medicine
dc.subject1.6 Biological sciences
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.titleFailure or future? Exploring alternative antibacterials : a comparative analysis of antibiotics and naturally derived biopolymersen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/systematicreview

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