GFAP and NF expression in brain tissue in children and adults after fatal traumatic brain injury

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dc.contributor.authorBarzdina, Arta
dc.contributor.authorPilmane, Māra
dc.contributor.authorPētersons, Aigars
dc.contributor.institutionDepartment of Anaesthesiology, Intensive Care and Clinical simulations
dc.contributor.institutionInstitute of Anatomy and Anthropology
dc.contributor.institutionDepartment of Paediatric Surgery
dc.date.accessioned2021-11-01T12:25:01Z
dc.date.available2021-11-01T12:25:01Z
dc.date.issued2011
dc.description.abstractBackground and objectives. Still, there is almost no information about the role of biomarkers in the pathological processes of the brain in those patients, which die immediately after the injury, and those, which die several hours after the trauma. Design and Settings. A retrospective study. The human brain tissue material from the archive of the Institute of Anatomy and Anthropology in Riga Stradins University (RSU). Methods. We used the brain tissue material from the trauma and counterstroke spots of 28 patients. Brain tissue specimens were routinely fixed, embedded into paraffin, cut in 5 μm thick slides. For immuno-histochemistry we used monoclonal antibodies against NF proteins to detect axonal injury and monoclonal antibodies against GFAP to detect astrocytes. Results. Statistical correlation was seen between the lethal cases and survived in the brain tissue in the areas of counterstroke between lethal cases and survived for NF and GFAP presence (p=0.017) The data was compared, by dividing patients into groups of children and adults. Each of these groups was divided into 2 sub-groups. Statistically significant differences were noted between the lethal and the survived cases in the group of children for GFAP (Mann-Whitney U Test, p = 0.015) and in the group of adults for NF in the area of the counterstroke (Mann-Whitney U Test, p = 0.019). Conclusions. Higher quantities of intermediated filaments such as GFAP and NF are characteristic in the patients who survived after a head trauma in comparison to those, who died on the spot of the accident. Children under 2 years of age with severe head trauma have more dynamic glial cell reaction than other patients.en
dc.description.statusPeer reviewed
dc.format.extent694253
dc.identifier.citationBarzdina, A, Pilmane, M & Pētersons, A 2011, 'GFAP and NF expression in brain tissue in children and adults after fatal traumatic brain injury', Papers on Anthropology, vol. 20, pp. 51-62. https://doi.org/10.12697/poa.2011.20.07
dc.identifier.doi10.12697/poa.2011.20.07
dc.identifier.issn1736-7646
dc.identifier.otherunpaywall: 10.12697/poa.2011.20.07
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/6780
dc.language.isoeng
dc.relation.ispartofPapers on Anthropology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectsevere traumatic brain injury
dc.subjectsecondary brain injury
dc.subjectstructural brain damage
dc.subjectreactive astrocytes
dc.subjectglial fibrillary acidic protein
dc.subjectneurofilament
dc.subjectastrogliosis
dc.subject3.1 Basic medicine
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.titleGFAP and NF expression in brain tissue in children and adults after fatal traumatic brain injuryen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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