Von Willebrand Factor Antigen, Biomarkers of Inflammation, and Microvascular Flap Thrombosis in Reconstructive Surgery

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dc.contributor.authorRocans, Rihards Peteris
dc.contributor.authorZarins, Janis
dc.contributor.authorBine, Evita
dc.contributor.authorMahauri, Insana
dc.contributor.authorDeksnis, Renars
dc.contributor.authorCitovica, Margarita
dc.contributor.authorDonina, Simona
dc.contributor.authorVanags, Indulis
dc.contributor.authorGravelsina, Sabine
dc.contributor.authorVilmane, Anda
dc.contributor.authorRasa-Dzelzkaleja, Santa
dc.contributor.authorMamaja, Biruta
dc.contributor.institutionDepartment of Anaesthesiology, Intensive Care and Clinical simulations
dc.contributor.institutionInstitute of Microbiology and Virology
dc.date.accessioned2024-10-22T14:55:02Z
dc.date.available2024-10-22T14:55:02Z
dc.date.issued2024-09-12
dc.descriptionPublisher Copyright: © 2024 by the authors.
dc.description.abstractBackground: Microvascular flap surgery has become a routine option for defect correction. The role of von Willebrand factor antigen (VWF:Ag) in the pathophysiology of flap complications is not fully understood. We aim to investigate the predictive value of VWF:Ag for microvascular flap complications and explore the relationship between chronic inflammation and VWF:Ag. Methods: This prospective cohort study included 88 adult patients undergoing elective microvascular flap surgery. Preoperative blood draws were collected on the day of surgery before initiation of crystalloids. The plasma concentration of VWF:Ag as well as albumin, neutrophil-to-lymphocyte ratio (NLR), interleukin-6, and fibrinogen were determined. Results: The overall complication rate was 27.3%, and true flap loss occurred in 11.4%. VWF:Ag levels were higher in true flap loss when compared to patients without complications (217.94 IU/dL [137.27–298.45] vs. 114.14 [95.67–132.71], p = 0.001). Regression analysis revealed the association between VWF:Ag and true flap loss at the cutoff of 163.73 IU/dL (OR 70.22 [10.74–485.28], p = 0.043). Increased VWF:Ag concentrations were linked to increases in plasma fibrinogen (p < 0.001), C-reactive protein (p < 0.001), interleukin-6 (p = 0.032), and NLR (p = 0.019). Conclusions: Preoperative plasma VWF:Ag concentration is linked to biomarkers of inflammation and may be valuable in predicting complications in microvascular flap surgery.en
dc.description.statusPeer reviewed
dc.format.extent10
dc.format.extent743071
dc.identifier.citationRocans, R P, Zarins, J, Bine, E, Mahauri, I, Deksnis, R, Citovica, M, Donina, S, Vanags, I, Gravelsina, S, Vilmane, A, Rasa-Dzelzkaleja, S & Mamaja, B 2024, 'Von Willebrand Factor Antigen, Biomarkers of Inflammation, and Microvascular Flap Thrombosis in Reconstructive Surgery', Journal of clinical medicine, vol. 13, no. 18, 5411. https://doi.org/10.3390/jcm13185411, https://doi.org/10.3390/jcm13185411
dc.identifier.doi10.3390/jcm13185411
dc.identifier.issn2077-0383
dc.identifier.otherMendeley: aecbdf0d-acb4-373f-9adc-7e9e02c75b6d
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/16797
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85205113086&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofJournal of clinical medicine
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectflap loss
dc.subjectmicrovascular flap complications
dc.subjectmicrovascular flap thrombosis
dc.subjectneutrophil-to-lymphocyte ratio
dc.subjectreconstructive surgery
dc.subjectvon Willebrand factor antigen
dc.subject3.2 Clinical medicine
dc.subject3.1 Basic medicine
dc.subject1.6 Biological sciences
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral Medicine
dc.titleVon Willebrand Factor Antigen, Biomarkers of Inflammation, and Microvascular Flap Thrombosis in Reconstructive Surgeryen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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